Task Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: ApoE Late CNS/CVD
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
  • Aim 1: investigate late CNS/CVD Effects of Simplified 5-ion Mixed Field Beam (normalized to 500 mGy) GCR IRR in Male & Female AD Tg and WT Mice.

  • Aim 2: investigate Late CNS/CVD Effects of Simplified 5-ion Mixed Field Beam IRR in Male and Female APP/E3 and APP/E4 Tg and WT Mice.

  • Aim 3: investigate Acute and Late CNS and CVD Effects of Simplified 5-ion Mixed Field Beam Space Radiation on Human Cells In Vitro

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
You are here!TaskSex- and Apo E-specific late CNS and cardiovascular effects of space radiation

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
You are here!TaskSex- and Apo E-specific late CNS and cardiovascular effects of space radiation

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskSex- and Apo E-specific late CNS and cardiovascular effects of space radiation