Task Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: CNS Biomarkers of RT Toxicity
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
  • Aim 1: Identify clinical characteristics, biofluid biomarkers and imaging features on baseline and follow-up multiparametric MRI that predict for cognitive decline following radiation exposure to the brain.
  • Aim 2: Evaluate the relationship between changes in specific aspects of cognitive function with radiation dosimetry in the whole brain and brain subregions in patients receiving radiation to the brain.
  • Aim 3: Identify early changes in multiparametric MRI measures that predict for subsequent changes in brain structure following radiation to the brain in preclinical and clinical studies.

 

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Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskQuantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!TaskQuantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation