Short Title:
CNS Biomarkers of RT Toxicity
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
- Aim 1: Identify clinical characteristics, biofluid biomarkers and imaging features on baseline and follow-up multiparametric MRI that predict for cognitive decline following radiation exposure to the brain.
- Aim 2: Evaluate the relationship between changes in specific aspects of cognitive function with radiation dosimetry in the whole brain and brain subregions in patients receiving radiation to the brain.
- Aim 3: Identify early changes in multiparametric MRI measures that predict for subsequent changes in brain structure following radiation to the brain in preclinical and clinical studies.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
The deliverable will be an evaluation of MRI as noninvasive imaging modality for detection of early indicators of cerebrovascular and CNS decrements following radiotherapy.
Internal Customers:
None
External Customers:
None
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
The deliverable will be an evaluation of biofluid markers and functional cognitive parameters for detection of early indicators of CNS decrements following radiotherapy
Internal Customers:
None
External Customers:
None