Task Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CNS Biomarkers of RT Toxicity
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
  • Aim 1: Identify clinical characteristics, biofluid biomarkers and imaging features on baseline and follow-up multiparametric MRI that predict for cognitive decline following radiation exposure to the brain.
  • Aim 2: Evaluate the relationship between changes in specific aspects of cognitive function with radiation dosimetry in the whole brain and brain subregions in patients receiving radiation to the brain.
  • Aim 3: Identify early changes in multiparametric MRI measures that predict for subsequent changes in brain structure following radiation to the brain in preclinical and clinical studies.

 

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCNS - 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human data be used to estimate late CNS risks to astronauts from GCR and SPE?
You are here!TaskQuantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapBMed9: We need to understand long term astronaut health for long duration exploration missions and find the best methods to promote long term post-mission behavioral health.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskQuantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskQuantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation