Task Hyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: AG HDBR-Hyper.Campus Neuroplasticity
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

This investigation is part of a complement of studies evaluating physiological, behavioral, and performance changes related to artificial gravity.

Aim 1: Investigate the effects of Head Down Bed Rest (HDBR) with and without artificial gravity on gray and white matter volume, subcortical volume, myelination, functional connectivity and task related brain activation.

Aim 2: Investigate the effects of HDBR with and without artificial gravity on cognitive performance.

Aim 3: Investigate the effects of HDBR with and without artificial gravity on biochemical markers of stress and neuroplasticity.

Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskHyper.Campus-Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest