Task Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: AG HDBR - Neurocognitive Declines CM
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Other:
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

A recently completed 70-day 6° head down tilt bed rest study examined a range of brain structural, brain functional, sensorimotor and cognitive metrics as outcome measures. Here, we select those that are sensitive to this spaceflight analog environment as outcome metrics for the following aims:

Aim 1) Determine whether 30 minutes per day of supine centrifugation +1Gz at the heart is effective at mitigating declines in brain structure, brain function, sensorimotor and cognitive performance induced by 60 days of 6° head down tilt bed rest in comparison to a control group that is not exposed to AG.


Aim 2) Determine whether centrifugation is more effective and better tolerated as a countermeasure when it is delivered continuously for 30 minutes or in six, five minute sessions separated by breaks of five minutes each.


Aim 3) Identify predictors of individual differences in bed rest and AG responses. We will examine whether pre bed rest measures of brain structure, brain function, and genotype for a few targeted single nucleotide polymorphisms (snps, COMT, DRD2, BDNF, alpha2-adrenergic receptor gene) are predictive of changes in sensory, motor, and cognitive function occurring in association with bed rest, and whether they also predict AG tolerance. We will combine data collected here with those we are acquiring in two ongoing NSBRI funded “predictors” studies to increase our predictive power. 

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