Task Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: AG HDBR - Neurocognitive Declines CM
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

A recently completed 70-day 6° head down tilt bed rest study examined a range of brain structural, brain functional, sensorimotor and cognitive metrics as outcome measures. Here, we select those that are sensitive to this spaceflight analog environment as outcome metrics for the following aims:

Aim 1) Determine whether 30 minutes per day of supine centrifugation +1Gz at the heart is effective at mitigating declines in brain structure, brain function, sensorimotor and cognitive performance induced by 60 days of 6° head down tilt bed rest in comparison to a control group that is not exposed to AG.


Aim 2) Determine whether centrifugation is more effective and better tolerated as a countermeasure when it is delivered continuously for 30 minutes or in six, five minute sessions separated by breaks of five minutes each.


Aim 3) Identify predictors of individual differences in bed rest and AG responses. We will examine whether pre bed rest measures of brain structure, brain function, and genotype for a few targeted single nucleotide polymorphisms (snps, COMT, DRD2, BDNF, alpha2-adrenergic receptor gene) are predictive of changes in sensory, motor, and cognitive function occurring in association with bed rest, and whether they also predict AG tolerance. We will combine data collected here with those we are acquiring in two ongoing NSBRI funded “predictors” studies to increase our predictive power. 

Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskDoes Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskDoes Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?