Short Title:
CBS Facility/Animal Translation Standards
Responsible HRP Element:
Human Factors and Behavioral Performance
Collaborating Org(s):
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Human Health Countermeasures (HHC) Element |
Space Radiation (SR) Element |
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Funding Status:
Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
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Aims:
Directed study to determine/develop standardization and recommendations related to animal handling, research facility (e.g., volume, lighting, sound, etc.) & animal/rodent type (species/strains) to increase reliability & validity of animal to human translational research yields by increasing standardization between radiobiological and neurobehavioral methodology, identification and application of genotype to phenotype, biomarkers, and to regional pathophysiology related to operationally-relevant brain performance pathways. From biomarkers to performance measures, it is vital to standardize measurements and tests across PIs for this integrated approach to ensure the reproducibility, reliability, and robustness of tests.
Category:
Requirement
Subcategory:
Description:
-Recommendation for standard testing conditions and tissue handling for future CBS research (focus on translational models to increase confidence in animal to human predictive models)
-biomarkers (leveraging cross-cutting projects inputs)
-testing/measurements/questionnaires linked to operational performance
-standardized animal conditions & models for use in integrated approaches to assess synergistic effects of GCRsim mixed field radiation exposure effects on CNS in varying conditions of isolation & confinement, and altered gravity-like sensorimotor impacts in order to contribute to computaional modeling cross-cutting project for heuristic reverse translations
-Appropriate model selection by leveraging biomarker & computaional modeling cross-cutting projects for robust methodological protocols to increase predictive validity for neurophysiologically relevant translational insights & models to increase likelihood of identifying/predicting impacts to operational performance.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None