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Task Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
Last Published:  07/31/19 10:05:33 AM (Central)
Task Book: Entry Unavailable
Principal Investigator: TBD
Short Title: CBS Facility/Animal Translation Standards
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Aims:
Directed study to determine/develop standardization and recommendations related to animal handling, research facility (e.g., volume, lighting, sound, etc.) & animal/rodent type (species/strains) to increase reliability & validity of animal to human translational research yields by increasing standardization between radiobiological and neurobehavioral methodology, identification and application of genotype to phenotype, biomarkers, and to regional pathophysiology related to operationally-relevant brain performance pathways. From biomarkers to performance measures, it is vital to standardize measurements and tests across PIs for this integrated approach to ensure the reproducibility, reliability, and robustness of tests.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskDetermination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM26: Determine if exposure to long-duration spaceflight leads to neural structural alterations and if this remodeling impacts cognitive and functional performance.
You are here!TaskDetermination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance
RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskDetermination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance