Short Title:
CBS Data Mining (Mulavara)
Responsible HRP Element:
Human Factors and Behavioral Performance
Collaborating Org(s):
|
Human Health Countermeasures (HHC) Element |
Space Radiation (SR) Element |
|
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
|
|
Aims:
Literature review and assessment of NASA-funded current and completed research findings relevant to this integrated risk. Identify behavioral and physiological (biomarker) cellular, molecular changes & brain regions linked to specific effects of targeted GCR simulation ions, simulated altered gravity stressor and/or space flight with translational relevance to operational performance measures. Identify Brain Performance Pathway neural circuitry responsible for operationally-relevant behavior characteristics to determine similar neuronal circuits maintaining coherent functions; assess artificial stimulation of the particular network (sensitive to CBS means—radiation, isolation & confinement, altered gravity) that generate predicted responses; and identify biomarkers that influence or act as the carriers of the network activity (neurotransmitters and other biomarkers with messenger activity) that predict the relevant behavioral changes.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-Summary of existing research results
-Identification of operationally-relevant brain performance pathways (map of anatomical regions to performance outcomes)
-Identification of knowledge gaps
-Recommendations for specific areas needing further research
-Biomarker candidates to GRC modeling cross-cutting project
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None