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Task Research Review: Neurobehavioral Biomarkers Performance/Pathway
Last Published:  07/30/21 01:05:34 PM (Central)
Task Book: Entry Unavailable
Principal Investigator: Desai, Rajeev
Short Title: CBS RR: Neurobehavioral Biomarkers Performance/Pathway (Desai)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Original Study Aims
Integrated research review for identifying neurobehavioral biomarkers: due to the effects of spaceflight stressors of radiation, altered gravity and isolation/confinement, and cutting-edge neuroscience results from psychopathology related to stress and vulnerabilities to psychiatric disorders; to identify correlative contributions of  brain regions identified as relevant to operational performance.  Determine specific neurobehavioral biomarkers from tissue dose variation, associated biomarkers for human & rodent cognition and performance. Incorporate Space Biology cross-cutting biomarker project from spaceflight hazards.

CBS Supplement Aims
  1. Complete neurochemical analysis from the Pre frontal cortex (PFC) and Ventral Tegmental Area (VTA) in a full cohort of mice exposed to acute or chronic GCR vs controls (n = 10-12/group). Neurochemical data will be related to the completed neurobehavioral (economic demand and PVT) data in these mice.
  2. Impact of mild sleep deprivation on a) neurochemical signatures in the VTA and PFC, b) behavior performance on economic demand, PVT, and an object location memory (OLM)/updating task that vary in difficulty, address different aspects of cognition.


 
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskResearch Review: Neurobehavioral Biomarkers Performance/Pathway