HRR - Task - Research Review: Neurobehavioral Biomarkers Performance/Pathway

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Research Review: Neurobehavioral Biomarkers Performance/Pathway

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Desai, Rajeev

Short Title: CBS RR: Neurobehavioral Biomarkers Performance/Pathway (Desai)

Responsible HRP Element: Human Factors and Behavioral Performance

Collaborating Org(s):

Human Health Countermeasures (HHC) Element

Space Radiation (SR) Element

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:
Original Study Aims
Integrated research review for identifying neurobehavioral biomarkers: due to the effects of spaceflight stressors of radiation, altered gravity and isolation/confinement, and cutting-edge neuroscience results from psychopathology related to stress and vulnerabilities to psychiatric disorders; to identify correlative contributions of brain regions identified as relevant to operational performance. Determine specific neurobehavioral biomarkers from tissue dose variation, associated biomarkers for human & rodent cognition and performance. Incorporate Space Biology cross-cutting biomarker project from spaceflight hazards.

CBS Supplement Aims

Complete neurochemical analysis from the Pre frontal cortex (PFC) and Ventral Tegmental Area (VTA) in a full cohort of mice exposed to acute or chronic GCR vs controls (n = 10-12/group). Neurochemical data will be related to the completed neurobehavioral (economic demand and PVT) data in these mice.
Impact of mild sleep deprivation on a) neurochemical signatures in the VTA and PFC, b) behavior performance on economic demand, PVT, and an object location memory (OLM)/updating task that vary in difficulty, address different aspects of cognition.

Resources (None Listed)

Deliverables (2)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
-Neurobehavioral biomarkers (blood, behavioral, etc) identified and linked to past CBS research that correlate with the human behavior and performance.
-Identification of positive biomarker statuses associated with adverse outcome pathways and/or indicate greater possibility of developing neurocognitive disorders.
-Provide conceptual model and heuristic for use in translational and computational models for dose-effect research. Computational models to identify potential operationally-relevant performance linkages to brain’s modular network organization that is more adaptable to new environments and supporting complex behaviors and sub-networks that support “associative” processes like executive function. Current research suggest that more modular brain networks enable complex cognitive processes and neuroplasticity and, further, may provide insight into the mechanisms underlying the effectiveness of interventions of potential relevance in mitigating integrated risks.

Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
CBS Supplement Deliverables

1.The data set will permit mapping GCR-induced alterations in neurochemical signatures in a key brain performance pathway (i.e., projections from VTA to PFC) that is involved in neurobehavioral and complex cognitive processes, including cognitive control/flexibility, reward-based learning, and attention/vigilance.

2.Provide the baseline information necessary to critically evaluate if/how a carefully controlled sleep deprivation paradigm alters endpoints that can be functionally linked to neurobehavioral performance

Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None

Mappings

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

BMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?

BMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?

BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Research Review: Neurobehavioral Biomarkers Performance/Pathway

Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SM-104: Evaluate how weightlessness-induced changes in sensorimotor/vestibular function relate to and/or interact with changes in other brain functions (sleep, cognition, attention).

Research Review: Neurobehavioral Biomarkers Performance/Pathway

Related Tasks (326)

Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight