Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS POL/PEL Standard Update
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Aims:
Directed effort to integrate initial research results, compose draft POLs for use in developing PELs.  Assess "synergistic" effects of integtrated risks.  Initial "in progress review" to  gain approval through the required control boards  for needed updates (BRES, HSRB, etc.). The conceptual basis within the CBS Integrated Research plan anticipates the need to approach operationally-relevant performance POLs with an openness in considering how a synergistic effect may result in a decrement of performance that is perhpas not most effectively represented in the same way a PEL represents a cancer risk from space radiation. Since the focus of a Performance Outcome Level does not necessarily reflect “pathology”, the representation to identify “integrated pathways” for the three risks, indicates the need to ensure we understand (and parse out) the potential vs combined effects on operational performance. That performance may not rise to the “pathological-level” associated with “health concerns” only; but rather prior to getting to pathological level of concern, there are likely detectable decrements of operational performance that are of operational concern (e.g., a reaction time that slowed on average by 10% may not be pathological but might be of great concern is a maneuver is required that requires a reaction time closer to 100% of the crewmember’s preflight level of performance).  In addition, individual differences in one’s lifestyle, family history etc. can all play a role in one’s cancer risk due to radiation exposure but these inter-individual differences are seldom, if ever, considered in developing PELs for radiation exposure.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskIntegrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM6.1: Determine if sensorimotor dysfunction during and after long-duration spaceflight affects ability to control spacecraft and associated systems.
GapCBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.
You are here!TaskIntegrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskIntegrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update