HRR - Task - Determine & Validate CNS/BMed/SM (CBS) relevant operational measures for integrated POLs and identify Research Measures for EM missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Dose Tracker Application for Monitoring Crew Medication Usage, Symptoms and Adverse Effects During Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea, Active)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Effects of emotional stress on the cardiovascular system (Stress and CV Health-TBD, Planned)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Expanded Longitudinal Assessment of Crew Sensorimotor Function (TBD)

Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Effects of Retronasal Smelling, Variety, and Choice on Appetite and Satiety

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Standardized “Pre-flight” Exercise Tests to Predict Performance during Extravehicular Activities in a Lunar Environment

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Sensorimotor Assessment and Rehabilitation Apparatus: Procedures and Equipment (Schubert)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Robust Human-System Interface Design for Spaceflight-Induced Environments (Interface Design-Stone, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

DEFERRED: Validation of Exploration Atmosphere Prebreathe Protocol

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Physiological Factors Contributing to Postflight Changes in Functional Performance (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Development of Countermeasures to Enhance Sensorimotor Adaptation (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Integrated Resistance and Aerobic Training Study

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Assessment of Operator Proficiency Following Long-Duration Spaceflight (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Galvanic Vestibular Stimulation (GVS) as an Analogue of Post-flight Sensorimotor Dysfunction (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Advanced Displays for Efficient Training and Operation of Robotic Systems (Robotic Systems-Oman, Completed)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Development of Countermeasures to Aid Functional Egress from the Crew Exploration Vehicle Following Long-Duration Spaceflight (Mulavara)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Recovery Data Mining: Relationship Between In-Flight Exercise and Postflight Sensorimotor Performance. (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Performance Data Mining: Correlation Between Previous Performance Data with Clinical Observations. (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Biomechanical Analysis of Treadmill Locomotion on the International Space Station

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Flight Mission Task Assessments

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Promoting stress tolerance, adaptability and behavioral health via enhancing exercise protocols for LDEM

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?

Pharmacology Database

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Factors Contributing to Food Acceptability and Consumption, Mood, and Stress on Long-term Space Missions/Food Variety in Free-Living Adults

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Assessment of the Time Courses of Leg Muscle Strength and Performance Losses During Prolonged Spaceflight using MARES

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

DEFERRED: Development of an integrated sensorimotor countermeasure suite for spaceflight operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Developing Predictors of Sensorimotor Adaptability - ISS Flight Validation (TBD)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.

Effect of Sensorimotor Adaptation Following Long-Duration Spaceflight on Perception and Control of Vehicular Motion (Wood)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Evaluate Energy Expenditure During Long-duration (>3mo) Missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Individualized Stress Detection System

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Space Suit Simulator (S3) for Partial Gravity EVA Experimentation and Testing

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

ESPRIT: Exercise Sensing and Pose Recovery Inference Tool

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Redox Modulation of Skeletal Muscle Function in Microgravity

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Head-Eye Coordination during Simulated Orbiter Landings (Moore)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Spatial Reorientation of Sensorimotor Balance Control in Altered Gravity (Paloski)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Sensorimotor adaptation following exposure to ambiguous inertial motion cues (Wood)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Neurovestibular Aspects of Short-radius Artificial Gravity: Toward Comprehensive Counter Measure (Young)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Promoting Sensorimotor Response Generalizability: A Countermeasure to Mitigate Locomotor Dysfunction After Long-Duration Spaceflight (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Data mining activities for Sensorimotor Discipline (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

The Constant Force Resistive Exercise Unit (CFREU) for Multi-Functional Exercise

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Retrospective Analysis of Medication Usage During Long Duration Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Inflight pharmacokinetic and pharmacodynamic responses to medications commonly used in spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SMS CM Development - Medication Optimization (TBD)

Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Straight Ahead in Microgravity (Clement)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Selection Studies Retrospective

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Space Biochemistry Profile

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Net Habitable Volume Community of Practice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE/ACTIVE]

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Markers of Susceptibility to Neurobehavioral Decrements in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.

Multi-Use Near-Infrared Spectroscopy System for Spaceflight Health Applications

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Potential Subclinical Neurologic Changes in Astronauts due to Repeated Hypobaric Exposures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Modulation of Muscle Function by Lower Limb Loading during Space Flight

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Development of a Submaximal Cycling Protocol to Identify the Ventilatory Threshold in Astronauts: Application to Monitor Changes in Endurance Capacity in Response to Long-Duration Spaceflight Missions

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Compact, Controlled Force Crew Exercise System

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
	CBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.

Controlled Resistance Exercise Device

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Computer-Controlled Force Generator

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Functional immune alterations, latent Herpesvirus reactivation, physiological stress and clinical incidence onboard the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

New Crop Testing: Nutritional & Organoleptic Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS/ACTIVE]

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Vehicle NHV and Habitability Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Long-duration Microgravity on Fine Motor Control Skills

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.

Sensorimotor Integrative Countermeasure Development - Bedrest (TBD)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

Effects of Long-Duration Spaceflight on Training Retention

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Analog investigation of team resilience over time

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Understanding Key Components of Successful Autonomous Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Investigate shifts in team cognitive processes over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Investigate shifts in team motivation and morale over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Developing and Validating Sensor-based Measurement Strategies for Team Member Selection

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Individualized Real-Time Neurocognitive Assessment Toolkit (Cognition) for Space Flight Fatigue (ISS-12) (NSBRI)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting from Altered Gravity Levels (Young)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.

Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

STARwatch to Deliver Objective Sleep Measures for Spaceflight Operations (SBIR Phase 2)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS (Reaction Self-Test on ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight (ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.

Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Metrics and Methods for Real-Time Task Performance Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

In-flight Demonstration of Portable Load Monitoring Devices-Phase I: XSENS ForceShoe™

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

(ZAG/Otolith) Ambiguous Tilt and Translation Motion Cues After Spaceflight/ Otolith Assessment During Postflight Re-adaptation (Wood)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	CBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
	CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	CBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
	CBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
	CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?