Task CBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS Operational Measures Human Flight Validation
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
TBD
Aims:
In-flight monitoring of EM crew with ISS crew as controls, monitor synergistic effect of space radiation on Brain Performance Pathways linked to operationally-relevant performance tasks sensitive to BMed & SM risks for initial EM mission crew. These results are used in the development of baselines established from behavioral health and cognitive assessment tools that are critical to the development of operating (performance) and morbidity (medical) ranges.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskCBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
GapCBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.
GapCBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.
GapCBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.
You are here!TaskCBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived

RiskRisk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
You are here!TaskCBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived