Task CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS VNSCOR #1- Mechanisms of Radiation-Induced Neurobehavioral Deficits (Davis)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Nelson/Davis Virtual NSCOR: Revised Specific Aims: This research builds on previous studies that  demonstrated that proton and HZE exposures result in individual differences in deficits in sustained attention, but more general deficits in recognition memory. This current project is combined with "Responses to the Nervous System to Chronic, Low Dosed Charged Particle Irradiation" (PI: Nelson)(See below)
Aim 1a: This aim proposes to investigate the time-course of radiation-induced deficits in sustained attention and social processing following protracted exposure to the five-ion galactic cosmic ray (GCR) simulation (total
dose: 0.5 Gy).
Aim 1b: This aim proposes to investigate the time-course of radiation-induced deficits in sustained attention and social processing following protracted exposure to the heavy ions only in the “five-ion” galactic cosmic ray (GCR) simulation. Thus, these exposures will include protracted exposures to 4He, 28Si, 16O, and 56Fe only (total dose: 0.5 Gy).
Aim 1c: This aim proposes to investigate the time-course of radiation-induced deficits in sustained attention and social processing following protracted exposure to protons (total dose: 0.5 Gy).
Aim 1d: This aim proposes to investigate the time-course of radiation-induced deficits in sustained attention and social processing following acute exposure to 4He ions (250 MeV/ n) at two different exposure doses (5 and 25 cGy).
Aim 2a: This aim proposes to investigate the time course of neuronal and other molecular markers following exposure to the GCR simulation (Aim 1a-c) and 4He exposure (Aim 1d). The time points for testing include: 7 days, 1 month, 3 months, and 6 months post-irradiation.
Aim 2b: This aim proposes to investigate the effects of silencing the regions of the medial prefrontal cortex, including the prelimbic, infralimbic, and anterior cingulate cortices, on sustained attention and social processing in order to determine possible mechanisms of radiation-induced changes in these behaviors.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskCBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing