Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: CBS GCRSim Exposure Response Study
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
This project “integrates” transdisciplinary approach with multiple research arms that use simulated galactic cosmic ray fields as the core feature with experimental design and conceptualization to assess interaction and time order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (sensorimotor responses to simulated microgravity). This project will use standardized handling and behavioral tests, assess brain physiology (including Blood-Brain-Barrier patency and function), molecular signaling, biomarker changes, and lead to computational modeling to characterize and predict changes in operationally-relevant “Brain Performance Pathways”. For purposes of this solicitation, NASA defines “Brain Performance Pathways” as the neural circuitry and associated molecular, cellular and physiological processes that underlie specific behaviors or sets of behaviors expressed in animal models that are translatable to humans.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskSHARE/[TBD] GCRsim Exposure Response Study (NRA)