Short Title:
CBS GCRSim Exposure Response Study
Responsible HRP Element:
Human Factors and Behavioral Performance
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Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| Other: |
| Space Radiation (SR) Element |
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Funding Status:
Planned-Funded - Task expected to be within budget
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Procurement Mechanism(s):
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Aims:
This project “integrates” transdisciplinary approach with multiple research arms that use simulated galactic cosmic ray fields as the core feature with experimental design and conceptualization to assess interaction and time order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (sensorimotor responses to simulated microgravity). This project will use standardized handling and behavioral tests, assess brain physiology (including Blood-Brain-Barrier patency and function), molecular signaling, biomarker changes, and lead to computational modeling to characterize and predict changes in operationally-relevant “Brain Performance Pathways”. For purposes of this solicitation, NASA defines “Brain Performance Pathways” as the neural circuitry and associated molecular, cellular and physiological processes that underlie specific behaviors or sets of behaviors expressed in animal models that are translatable to humans.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-GCRSim exposure response for selected measures
-Experimental evidence and predictive models for Brain Performance Pathways affected by space-like radiation, stress, and altered gravity, with identification of component dose and environmental factor exposure level-effects, compensatory pathways, and adverse outcome mechanistic pathways whose features can be organized into heuristic computational models and facilitate countermeasure development and testing.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None