Short Title:
CBS Stress Response, Cross-species Homology Study NHPs
Responsible HRP Element:
Human Factors and Behavioral Performance
Collaborating Org(s):
|
Human Health Countermeasures (HHC) Element |
Space Radiation (SR) Element |
|
Funding Status:
Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
|
|
Aims:
Research project focused on developing scientifically plausable, heuristic, computational models using Non-Human Primates (NHP) and radiation exposures (both clinical and space relevant, in combination with other CBS realted spaceflight stressors) in order to assess, characterize and derive and valdiate operationally-relevant models of performance outcome levels relative to radiation exposures (in combination with other CBS realted spaceflight stressors), dose effects and countermeasures for CBS integrated risk exposures in humans. An important aspect of this effect involves the conceptualization of research that is "reverse translation" in which consideration is given to the specific biological markers with significant operationally-relevant performance consequences are first determined in human models and then applied to an animal model to see if they exist and that they reflect the same performance decrements as evidenced in humans. This approach will facilitate the identification of novel biomarkers linked to different levels of performance (impact by CBS synergistic risks) with the introduction of CBS integrated risk at different stages of mission-relevant performance demands in the animal models. This also offers the potential to identify biomarkers related to the brain performance pathways.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
-Integrated stress response linked to outcome measures
-Cross-species homology of selected outcome measures
-Identify early markers of molecular and/or cellular changes in order to elucidate the molecular cascades linked to performance outcomes changes that result from the synergistic CBS risks.
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None