Short Title:
Computational Modeling for CBS Synergistic/Order Effects of Spaceflight Hazards
Responsible HRP Element:
Human Factors and Behavioral Performance
Collaborating Org(s):
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Human Health Countermeasures (HHC) Element |
Space Radiation (SR) Element |
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Funding Status:
Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
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Aims:
This CBS Integrated Research topic is proposed to assemble a multidisciplinary team into an “integrated” Virtual NSCOR with multiple research arms that use GCRsim mixed field as the core with experimental design and with translational conceptualizations that leverage the Research Domain Criteria (RDoC) to provide computational model to characterize and predict changes in operationally-relevant Brain Performance Pathways using animal models to assess distinct processes of cognitive and behavioral changes of relevance to operationally-relevant performance, linking neural processes and biomarkers to these constructs in order to assess synergistic and order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (hindlimb unloading), using standardized handling and behavioral tests, brain physiology changes (to include Blood-Brain-Barrier changes), molecular signaling with biomarker changes. This approach is also intended to help develop the framework for performance outcome limits and determine more targeted countermeasures for intervention.
Category:
Technology or Tool
Subcategory:
Description:
-Predictive models for Brain Performance Pathways (with mapping to compensatory pathways) affected by space-like radiation, stress, and altered gravity
-Identification of integrative dose-effects, along with mapping of compensatory pathways and adverse outcome pathway heuristic computational modeling and countermeasures
-Heuristic model of performance decrements linked to neural processes and biomarkers
-Proposed model/framework for identifying POLs
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None