Task Computational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Computational Modeling for CBS Synergistic/Order Effects of Spaceflight Hazards
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
This CBS Integrated Research topic is proposed to assemble a multidisciplinary team into an “integrated” Virtual NSCOR with multiple research arms that use GCRsim mixed field as the core with experimental design and with translational conceptualizations that leverage the Research Domain Criteria (RDoC) to provide computational model to characterize and predict changes in operationally-relevant Brain Performance Pathways using animal models to assess distinct processes of cognitive and behavioral changes of relevance to operationally-relevant performance, linking neural processes and biomarkers to these constructs in order to assess synergistic and order-effects of radiation exposure (RE), isolation & confinement stress (ICS), and SM (hindlimb unloading), using standardized handling and behavioral tests, brain physiology changes (to include Blood-Brain-Barrier changes), molecular signaling with biomarker changes. This approach is also intended to help develop the framework for performance outcome limits and determine more targeted countermeasures for intervention.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskComputational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed1: We need to identify and validate countermeasures that promote individual behavioral health and performance during exploration class missions.
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
GapCBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.
GapCBS-SM24: Determine if the individual capacity to produce adaptive change (rate and extent) in sensorimotor function to transitions in gravitational environments can be predicted with preflight tests of sensorimotor adaptability.
GapCBS-SM28: Develop a sensorimotor countermeasure system integrated with current exercise modalities to mitigate performance decrements during and after spaceflight.
You are here!TaskComputational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskComputational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance

RiskRisk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
You are here!TaskComputational Modeling for CBS Synergistic and Order Effects of Radiation Exposure, Stress, and Hindlimb Unloading to Identify Operationally-Relevant Brain Physiology, Biomarkers, and Performance