Short Title:
CBS BioNutritional CMs Data Mining (Smith)
Responsible HRP Element:
Human Factors and Behavioral Performance
Collaborating Org(s):
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Human Health Countermeasures (HHC) Element |
Space Radiation (SR) Element |
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Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
1. Complete a systematic review of the literature to describe the interrelationship of nutrition (and specific nutrients) with CBS systems and risks. Identify potential nutritional countermeasures of relevance to the CBS systems and risks, focusing on how these countermeasures may influence performance outcomes.
a. Development of a comprehensive database of relevant research that allows for an assessment of the methodological quality of included studies.
b. Summarize the extent, range, and nature of nutritional countermeasures that potentially mitigate the individual and synergistic impacts of the three CBS risks.
2. Summarize relevant research findings in order to provide a scientifically plausible rationale for an integrated risk mitigation approach using nutritional countermeasures while addressing the implications for these countermeasures in the context of missionrelated factors (e.g., immune system alterations, food systems) related to crew health and operational performance.
a. Identify research conducted with animals to identify plausible approaches for use of animal models in the identification and validation of nutritional countermeasures for use in the CBS Integrated Research Plan.
3. Identify biomarkers associated with nutrition and nutritional countermeasures and their relevance to a) structural and functional changes to brain, b) associated dose-response
effects related to physiological changes, and/or c) real-time performance outcomes.
4. Use results of this literature-based research to identify gaps in knowledge related to a) potential synergistic effects of deep space travel (e.g., impacts of isolation and confinement and altered gravity, and radiation effects), b) potential use of CMs to prevent or intervene, and c) potential biomarkers for both human spaceflight and translational models. In particular, identify research gaps in the existing literature related to nutritional CMs as they relate to:
- Mechanisms
- Pathways
- Order effects validation
- Biomarkers
- Potential interactions with other countermeasures
- development/refinement of standards
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
This project is focused on nutrition, and seeks to compile a review of existing literature relating nutrition and the CBS risks. Specifically, this review will:
1. identify nutrition research related to an integrated risk posed by radiation, isolation, confinement, and the sensorimotor adaptations of altered gravity
2. identify the utility of nutrient (and/or related metabolite) biomarkers in assessing this risk.
3. identify potential benefits of nutrient countermeasures for prevention and/or
intervention to ensure sustained crew health and performance
4. identify plausible biochemical pathways that account for the effectiveness of the countermeasures
Internal Customers:
Human Factors and Behavioral Performance
Human Health Countermeasures
Space Radiation
External Customers:
None