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Task BioNutritional Countermeasures Data Mining (Completed)
Last Published:  04/20/22 11:43:24 AM (Central)
Task Book: Entry Unavailable
Principal Investigator: Smith, Scott
Short Title: CBS BioNutritional CMs Data Mining (Smith)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
1. Complete a systematic review of the literature to describe the interrelationship of nutrition (and specific nutrients) with CBS systems and risks. Identify potential nutritional countermeasures of relevance to the CBS systems and risks, focusing on how these countermeasures may influence performance outcomes.
a. Development of a comprehensive database of relevant research that allows for an assessment of the methodological quality of included studies.
b. Summarize the extent, range, and nature of nutritional countermeasures that potentially mitigate the individual and synergistic impacts of the three CBS risks.
2. Summarize relevant research findings in order to provide a scientifically plausible rationale for an integrated risk mitigation approach using nutritional countermeasures while addressing the implications for these countermeasures in the context of missionrelated factors (e.g., immune system alterations, food systems) related to crew health and operational performance.
a. Identify research conducted with animals to identify plausible approaches for use of animal models in the identification and validation of nutritional countermeasures for use in the CBS Integrated Research Plan.
3. Identify biomarkers associated with nutrition and nutritional countermeasures and their relevance to a) structural and functional changes to brain, b) associated dose-response
effects related to physiological changes, and/or c) real-time performance outcomes.
4. Use results of this literature-based research to identify gaps in knowledge related to a) potential synergistic effects of deep space travel (e.g., impacts of isolation and confinement and altered gravity, and radiation effects), b) potential use of CMs to prevent or intervene, and c) potential biomarkers for both human spaceflight and translational models. In particular, identify research gaps in the existing literature related to nutritional CMs as they relate to:
- Mechanisms
- Pathways
- Order effects validation
- Biomarkers
- Potential interactions with other countermeasures
- development/refinement of standards
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-104: Given the potentially negative spaceflight associated CNS changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated modifications to habitat/vehicle to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
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