Task Research Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS RR: HCAAM Intelligent System: Monitoring & CMs Performance Pathways
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Solicited
Aims:
-Conduct Research Review focused on potential human system adaptations with autonomous systems and habitat in order to maintain operationally-relevant performance by leveraging both countermeasures  (CM) and Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System that monitors Brain Performance Pathways and then responds with appropriate countermeasures to mitigate risk and/or compensate for decrements in performance throughout mission.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCNS - 7: What are the best shielding approaches to protect against CNS risks, and are shielding approaches for CNS and cancer risks synergistic?
You are here!TaskResearch Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapBMed7: We need to identify and validate effective methods for modifying the habitat/vehicle environment to mitigate the negative psychological and behavioral effects of environmental stressors (e.g., isolation, confinement, reduced sensory stimulation) likely to be experienced in the long duration spaceflight environment.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM2.1: Determine the changes in sensorimotor function over the course of a mission and during recovery after landing.
GapCBS-SM7.1: Determine if there are decrements in performance on functional tasks after long-duration spaceflight. Determine how changes in physiological function, exercise activity, and/or clinical data account for these decrements.
GapCBS-SM26: Determine if exposure to long-duration spaceflight leads to neural structural alterations and if this remodeling impacts cognitive and functional performance.
You are here!TaskResearch Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskResearch Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways

RiskRisk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
You are here!TaskResearch Review: Human Capabilities Assessment for Autonomous Missions (HCAAM) Intelligent System: Monitoring & Countermeasures Performance Pathways