Task A determination of bioactive proteins secreted by the human vasculature in response to low dose space radiation
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Bioactive proteins secreted by the human vasculature
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

 

Aim 1. Create RBEs for the vascular damage endpoints.

  • Aim 1a Carry out Gamma radiation studies at BNL for the determination of reference RBEs.
  • Aim 1b Carry out charged particle studies at BNL for the determination of RBEs

Aim 2. Identify the proteins secreted by the endothelial cells during angiogenesis and in mature human 3D micro-vessel tissue models in response to radiation.

  • Aim 2a Development of the proteomics assay.
  • Aim 2b Identify the proteins secreted by the endothelial cells during angiogenesis and in mature human 3 D micro-vessel tissue models in response to gamma radiation.
  • Aim 2c Identify the proteins secreted by the endothelial cells during angiogenesis and in mature human 3 D micro-vessel tissue models in response to the Simplified GCR sim.

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