Task Mechanical and gravitational countermeasures to ocular changes during strict head-down tilt bedrest (Marshall-Goebel)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: SANS CM Bedrest - LBNP
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:

 

This study aims to evaluate countermeasures that prevent or mitigate the signs and symptoms associated with Spaceflight Associated Neuro-ocular Syndrome (SANS) and SANS-related behavioral outcomes including sleep, as well as investigation of potential mechanisms by which SANS occurs in this ground-based analog.

The bed rest campaign will consist of four arms, each lasting 30 days. Three of the study arms are captured in this task:

  1. A 6° head-down tilt "no countermeasure" control arm.
  2. A 6° head-down tilt “mechanical countermeasures” arm to test 25mmHg of lower body negative pressure (LBNP) applied 6 hours/ day.

  3. A 6° head-down tilt bed rest arm, where 6 hrs. seated will be used as the countermeasure to be tested and compared to outcomes of the control and the mechanical countermeasure arm.


The specific aims of this study:

  1. To determine if daily exposure to actual (upright posture) and simulated (LBNP) hydrostatic pressure gradients prevents ocular and cerebral structural changes during 30 days of strict 6° head-down tilt bedrest.
  2. To determine if daily exposure to actual (upright posture) and simulated (LBNP) hydrostatic pressure gradients prevents ocular functional changes during 30 days of strict 6° head-down tilt bedrest.
  3. To determine if daily exposure to actual (upright posture) and simulated (LBNP) hydrostatic pressure gradients prevents vascular and cerebrospinal fluid changes during 30 days of strict 6° head-down tilt bedrest.
 
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