Task Effects of microgravity on ocular vascular hydrodynamics - ISS (Zawieja)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Rodent Vascular
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Background: Changes in retinal blood flow or pressure may contribute to the formation of cotton wool spots and optic disc edema. SANS sx may also result from ocular venous congestion and/or elevated venous compliance, disruption of the BRB, and/or reduction in ocular lymph flow.

 

Goal: Determine whether microgravity alters the structure and function of the ocular vasculature at the level of feed arteries, venous exchange and capacitance vessels, and lymph vessels.

Aims:

  1. Evaluate the effects of microgravity on ocular artery structure/function - Will test whether CRA flow velocity and vasomotor function and structure of ophthalmic arteries are affected after exposure to spaceflight

  2. Evaluate the effects of microgravity on ocular vein structure/function - Will test whether BRB integrity/microvascular hyperpermeability of venous exchange vessels and vascular reactivity of ophthalmic capacitance veins are affected

  3. Evaluate the effects of microgravity on ocular lymphatic structure/function - Will test whether the ocular lymphatic network and the phasic and tonic contractile function and structure of the large ophthalmic collecting lymphatics are affected after flight.

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