Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
In this proposal, the effects of a 60-day exposure to simulated microgravity (6° head down tilt
bedrest, HDBR) on the cerebral, ocular and vestibular systems with and without the intervention
of intermittent artificial gravity (AG, short-arm centrifugation) will be evaluated. Our
overarching objective is to reveal the effects of HDBR-induced headward fluid shifts as well as
the reversal of these hydrostatic pressure gradients with AG using innovative, integrated
techniques to provide novel insights into the physiological adaptations during simulated
microgravity.
Aims:
- To determine the between-group effects of 60 days HDBR alone versus HDBR with AG (2 different regimens) on the cerebral, ocular, and sensorimotor systems.
- To determine the within-group effects of the experimental conditions (60 days HDBR +/- AG) on the cerebral, ocular and sensorimotor systems compared to pre HDBR baseline.
- Assess the within and between group transient effects of AG (intervention groups) on cerebral and ocular systems using non-invasive technologies in the peri-centrifuge period.
Additional measures and data collections are also being performed on the subjects to create a non-CO2 control group for comparison to the Thirty-day CO2 Bedrest (VAPER) study (PI: S. Laurie).