HRR - Task - SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest

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SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry
Principal Investigator: Bershad, Eric

Short Title: Intermittent Rotation AGBRESA - Bershad

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:
In this proposal, the effects of a 60-day exposure to simulated microgravity (6° head down tilt

bedrest, HDBR) on the cerebral, ocular and vestibular systems with and without the intervention

of intermittent artificial gravity (AG, short-arm centrifugation) will be evaluated. Our

overarching objective is to reveal the effects of HDBR-induced headward fluid shifts as well as

the reversal of these hydrostatic pressure gradients with AG using innovative, integrated

techniques to provide novel insights into the physiological adaptations during simulated

microgravity.

Aims:

To determine the between-group effects of 60 days HDBR alone versus HDBR with AG (2 different regimens) on the cerebral, ocular, and sensorimotor systems.
To determine the within-group effects of the experimental conditions (60 days HDBR +/- AG) on the cerebral, ocular and sensorimotor systems compared to pre HDBR baseline.
Assess the within and between group transient effects of AG (intervention groups) on cerebral and ocular systems using non-invasive technologies in the peri-centrifuge period.

Additional measures and data collections are also being performed on the subjects to create a non-CO2 control group for comparison to the Thirty-day CO2 Bedrest (VAPER) study (PI: S. Laurie).

Resources (Ground Analog)

Deliverables (1)

Category:
Subcategory:

Description:

This study will provide a final report with relevant and valuable insights into the potential for intermittent AG as a countermeasure for the microgravity induced fluid redistribution pathology occurring during long-duration spaceflight.

Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None

Mappings

Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after G transitions.

SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-303: Test the efficacy of AG (centrifugation)-induced fluid shift versus other mechanical countermeasures.

SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest

Related Tasks (174)

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PRRs (3)

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Ground-Based Flight Analogs Bedrest [e.g., envihab, other bedrest facilities]
Number of Subjects	24

Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after G transitions.