Task Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Microgravity and Radiation CVD Effects
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1 will simulate a 6 month ISS human mission, determining the impact of simulated

weightlessness and space radiation [150 MeV protons (20 mGy), 1 GeV protons (20 mGy) and

600 MeV/n silicon (10 mGy)] on cardiac rhythm and risk for cardiac disease.


Specific Aim 2 will simulate a 3-3.5 year deep space human mission, determining the impact

of simulated weightlessness combined with components of galactic cosmic rays (60 % 1 GeV

protons, 20% 250 MeV/n helium, 10% 350 MeV/n oxygen and 10% 600 MeV/n silicon) with

total doses of 0.50 and 0.75 Gy plus appropriate controls on cardiac rhythm and risk for

cardiac disease.


Specific Aim 3 will determine the response to gamma radiation with and without simulated

weightlessness, to estimate relative biological effectiveness (RBE) for early clinically relevant

endpoints for cardiac rhythm and risk for cardiac disease. Rats will be irradiated with doses of

0.25, 0.5 Gy, 1.0 Gy and 2.0 Gy of 137Cs at Brookhaven National Laboratory alongside

experimental animals.


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