Task CBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS VNSCOR #2: Effects of GCRsim/HU/ICE on Immune, Performance with Dietary CM Dev (Ronca)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
The overall goal is to minimize risks in both male and female astronauts that are associated with long-term, deep space missions. This will be achieved to generate research results on biomarkers, brain morphology and function, performance pathways, and functional behavioral performance impairments, necessary inputs for computational human health risk models of combined space exposures. The successful completion of this work will provide a clear understanding of synergistic interactions between space environment factors in relation to crew health and performance during extended missions beyond the Van Allen belts.                                                                     
Aim 1: Determine dose dependence of acute ‘Five-Ion GCR Simulation’ exposure for immune, brain and behavioral performance responses in crew age-matched adult male and female mice. 
Aim 2: Determine effects of acute ‘Five-Ion GCR Simulation’ exposure singly and in combination with simulated microgravity and social isolation, on immune and nervous system responses in crew age-matched male and female mice mimicking deep space missions.
Aim 3: Determine efficacy of the dietary antioxidant, Nicotinamide Mononucleotide (NMN) in reversing immune, brain and behavioral/cognitive performance effects after acute ‘Five-Ion GCR Simulation’ exposure in socially isolated, IR and simulated microgravity exposed male and female mice, mimicking deep space missions.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 4: What are the most effective medical or dietary countermeasures to mitigate CNS risks? By what mechanisms are the countermeasures likely to work?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
GapCBS-SM26: Determine if exposure to long-duration spaceflight leads to neural structural alterations and if this remodeling impacts cognitive and functional performance.
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCBS VNSCOR #2: Oxidative stress and the neuroconsequences of spaceflight environment - Immune dysregulation and antioxidant dietary countermeasure efficacy