Task CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: CBS VNSCOR #2- Effects of GRCsim/HU/ICE on Behavior with Risk Prediction Model (Rosi)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
To ensure human safety during interplanetary space travel, we must understand the health risks of the stressors encountered in space, including ionizing radiation, confinement and altered gravity and develop mechanism-based models and tools to protect astronauts against negative effects of these stressors, especially those that affect behaviors critical for mission success. The central hypothesis of this proposal is that (a) exposure to CSS induces inflammatory responses and loss of synaptic integrity in behavior-controlling brain subregions that differ between males and females, (b) correlates of CNS inflammation are detectable in peripheral blood, and (c) quantitative measures of CNS tissue and plasma responses after CSS exposures can be used to build predictive models of differential susceptibility of males and females for long-term loss of sensorimotor, behavioral and cognitive functions.                                                    
Aim 1. Characterize the relative contributions of radiation, social and gravity stressors on sensorimotor, behavioral and cognitive functions and their possible synergistic interactions. 
Aim 2. Investigate the quantitative relationships between neuroinflammation and synaptic changes in mice with sensorimotor, behavioral and cognitive deficits following combined spaceflight stress.
Aim 3. Characterize the molecular profiles in peripheral blood of mice exposed to CSS to develop surrogate blood biomarkers of susceptibility and resistance for specific behavioral impairments.
Aim 4. Integrate the relationships between tissue damage markers and behavior phenotypes in male and female mice exposed to space stressors, and develop multivariate models that predict impaired performance for behaviors that are relevant to astronauts on deep space missions.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-105: Given the potentially negative spaceflight associated CNS/cognitive changes and behavioral experiences of stressors during long-duration missions (e.g., isolation, confinement, reduced sensory stimulation, altered gravity, space radiation), what are validated medical or dietary countermeasures to mitigate stressors impacting on CNS / cognition / behavioral health?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts