Task CBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS VNSCOR #2- Effects of GRCsim/HU/ICE on Behavior with Risk Prediction Model (Rosi)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
To ensure human safety during interplanetary space travel, we must understand the health risks of the stressors encountered in space, including ionizing radiation, confinement and altered gravity and develop mechanism-based models and tools to protect astronauts against negative effects of these stressors, especially those that affect behaviors critical for mission success. The central hypothesis of this proposal is that (a) exposure to CSS induces inflammatory responses and loss of synaptic integrity in behavior-controlling brain subregions that differ between males and females, (b) correlates of CNS inflammation are detectable in peripheral blood, and (c) quantitative measures of CNS tissue and plasma responses after CSS exposures can be used to build predictive models of differential susceptibility of males and females for long-term loss of sensorimotor, behavioral and cognitive functions.                                                    
Aim 1. Characterize the relative contributions of radiation, social and gravity stressors on sensorimotor, behavioral and cognitive functions and their possible synergistic interactions. 
Aim 2. Investigate the quantitative relationships between neuroinflammation and synaptic changes in mice with sensorimotor, behavioral and cognitive deficits following combined spaceflight stress.
Aim 3. Characterize the molecular profiles in peripheral blood of mice exposed to CSS to develop surrogate blood biomarkers of susceptibility and resistance for specific behavioral impairments.
Aim 4. Integrate the relationships between tissue damage markers and behavior phenotypes in male and female mice exposed to space stressors, and develop multivariate models that predict impaired performance for behaviors that are relevant to astronauts on deep space missions.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-SM26: Determine if exposure to long-duration spaceflight leads to neural structural alterations and if this remodeling impacts cognitive and functional performance.
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCBS VNSCOR #2: Probing the synergistic effects of radiation, altered gravity and stress on behavioral cognitive and sensorimotor functions to predict performance decrement in astronauts