Task CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS VNSCOR #2: Impact of GCRsim/HU/ICE /Sleep on Brain Function (Sanford)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
This project aims to determine the individual and synergistic effects of simulated microgravity (hindlimb suspension (HLS)), social isolation (SI) and space radiation (SR) on sleep, ability to cope with additional stress, and on temporal perception and sensorimotor function in male and female Wistar rats that show individual differences in stress resilience and vulnerability.
Aim 1: Effects of SI, HLS and SR on sleep architecture, activity, stress system responsivity, extinction learning, and anticipatory activity.
Aim 2. Determine synergistic effects of SR and SI and of SR and HLS on sleep architecture, activity, stress system responsivity, extinction learning, and anticipatory activity.
Aim 3. Determine synergistic effects of SR and SI and of SR and HLS on neural communication.
Aim 4. Determine synergistic effects of SR, SI and HLS on immune system.
Resources (None Listed)
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-101: We need to identify, quantify, and validate the key selection factors for astronaut cognitive and behavioral strengths (e.g., resiliency) and operationally-relevant performance threats for increasingly Earth independent, long-duration, autonomous, and/or long-distance exploration missions.
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-103: What are the validated, efficacious treatments (individual or Team-based) and/or countermeasures to prevent adverse behavioral conditions, CNS/neurological, and/or psychiatric disorders caused by either single and/or integrated exposures to spaceflight hazards during exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation