Task CBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS VNSCOR #2: Impact of GCRsim/HU/ICE /Sleep on Brain Function (Sanford)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
This project aims to determine the individual and synergistic effects of simulated microgravity (hindlimb suspension (HLS)), social isolation (SI) and space radiation (SR) on sleep, ability to cope with additional stress, and on temporal perception and sensorimotor function in male and female Wistar rats that show individual differences in stress resilience and vulnerability.
Aim 1: Effects of SI, HLS and SR on sleep architecture, activity, stress system responsivity, extinction learning, and anticipatory activity.
Aim 2. Determine synergistic effects of SR and SI and of SR and HLS on sleep architecture, activity, stress system responsivity, extinction learning, and anticipatory activity.
Aim 3. Determine synergistic effects of SR and SI and of SR and HLS on neural communication.
Aim 4. Determine synergistic effects of SR, SI and HLS on immune system.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed2: We need to identify and validate measures to monitor behavioral health and performance during exploration class missions to determine acceptable thresholds for these measures.
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-SM6.1: Determine if sensorimotor dysfunction during and after long-duration spaceflight affects ability to control spacecraft and associated systems.
GapCBS-SM26: Determine if exposure to long-duration spaceflight leads to neural structural alterations and if this remodeling impacts cognitive and functional performance.
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation

RiskRisk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
You are here!TaskCBS VNSCOR #2: Impact of inflight stress and sleep disturbances on brain function, neural communication and inflammation