Task Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS GCRsim, HU Effects on BPP (Raber)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
Aim 1. Determine the effects of mixed beam irradiation in the presence and absence of hindlimb unloading on behavioral and cognitive performance and determine whether these effects are associated with alterations in metabolic pathways in two pertinent brain regions in WAG rats.
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Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-107: What are the long-term changes and risks to astronaut health post-mission that, when using a continuity of care model, helps retrospectively identify and understand individual susceptibility (e.g., hereditary, dose, thresholds) to mitigate adverse CNS, cognitive, and behavioral health changes resulting from long-duration exploration missions, promoting the behavioral health of current and future crews?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskEffects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskEffects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.