Task Effects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: CBS GCRsim, HU Effects on BPP (Raber)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:
Aim 1. Determine the effects of mixed beam irradiation in the presence and absence of hindlimb unloading on behavioral and cognitive performance and determine whether these effects are associated with alterations in metabolic pathways in two pertinent brain regions in WAG rats.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskEffects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS adverse changes or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE?
GapCBS-CNS - 8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors, e.g., psychological (isolation and confinement), altered gravity (micro-gravity), stress, sleep deficiency, altered circadian rhythms, hypercapnea, altered immune, endocrine and metabolic function, or other?
You are here!TaskEffects of mixed beam irradiation in the presence and absence of Hindlimb Unloading on behavioral and cognitive performance and metabolic pathways in pertinent brain regions in WAG rats.