HRR - Task - Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

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Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Bouxsein, Mary

Short Title: Mouse G-Dose Response on JAXA-ISS (MHU-8)

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Other: JAXA

Space Biology Program

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

•Aim 1: Quantify effects of varying G-levels on neuromotor performance, as well as bone, muscle and joint structure and function in mice centrifuged aboard the ISS

•Aim 2: Determine cell and molecular mechanisms underlying the musculoskeletal and neuromotor response to microgravity and varying G-levels induced by centrifugation

Resources (Flight, Other)

Deliverables (3)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

A dose-response curve between 0 and 1G for musculoskeletal outcomes, including a) gait; b) grip strength; c) bone mass, microarchitecture, tissue quality and biomechanical strength; d) muscle fiber size, type, quality, and contractile properties; and e) cartilage and meniscus structure and composition.

Internal Customers:
Human Factors and Behavioral Performance
External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

A recommendation for G-threshold needed for a centrifugation countermeasure in microgravity

Internal Customers:
Human Health Countermeasures
External Customers:
None

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
An improved understanding of the protective health effects of partial gravity environments

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Osteo 6: How do skeletal changes due to spaceflight modify the terrestrial risk of osteoporotic fractures?

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Risk Of Early Onset Osteoporosis Due To Spaceflight

Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Osteo 6: How do skeletal changes due to spaceflight modify the terrestrial risk of osteoporotic fractures?

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

M2: Characterize in-flight and post-flight muscle performance.

M9: Identify and validate exploration countermeasure hardware for the maintenance of muscle function.

M14: Indentify adjuncts to exercise countermeasures that can be used to better mitigate muscle loss.

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Related Tasks (135)

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.