Task Markers of Vascular Risks Associated with Spaceflight Associated Neuro-ocular Syndrome - ISS (Hein)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CSF Biomarkers - ISS
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Objective:

To determine whether local vasoactive proteins and inflammatory cytokines in the CSF might provide useful biomarkers to monitor and address SANS.

Aims:

  1. Identify biomarkers of ocular vascular vasomotor function in the CSF of astronauts - Test whether concentrations of 4 vasoactive proteins in the CSF are altered in ISS crew.

  2. Identify biomarkers of vascular inflammation (inflammatory cytokines and products) in the CSF of astronauts.

  3. Correlate findings with physiological variables (RNFL/choroidal thickness, IOP; mean arterial BP; IJV pressure).

Hypothesis:

Spaceflight-induced dysfunction in the ocular vasculature leads to symptoms of SANS and will be associated with markers of vascular dysfunction in the CSF of affected astronauts.

  1. Long-duration spaceflight alters the levels of vasoactive biomarkers in the CSF that are linked to retinal vasomotor function, which will correlate with SANS symptoms.

  2. Long-duration spaceflight alters the levels of inflammatory cytokine biomarkers in the CSF linked to venular permeability and lymphatic transport function, which will correlate with SANS symptoms.

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