Short Title:
CSF Biomarkers - ISS
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Objective:
To determine whether local vasoactive proteins and inflammatory cytokines in the CSF might provide useful biomarkers to monitor and address SANS.
Aims:
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Identify biomarkers of ocular vascular vasomotor function in the CSF of astronauts - Test whether concentrations of 4 vasoactive proteins in the CSF are altered in ISS crew.
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Identify biomarkers of vascular inflammation (inflammatory cytokines and products) in the CSF of astronauts.
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Correlate findings with physiological variables (RNFL/choroidal thickness, IOP; mean arterial BP; IJV pressure).
Hypothesis:
Spaceflight-induced dysfunction in the ocular vasculature leads to symptoms of SANS and will be associated with markers of vascular dysfunction in the CSF of affected astronauts.
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Long-duration spaceflight alters the levels of vasoactive biomarkers in the CSF that are linked to retinal vasomotor function, which will correlate with SANS symptoms.
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Long-duration spaceflight alters the levels of inflammatory cytokine biomarkers in the CSF linked to venular permeability and lymphatic transport function, which will correlate with SANS symptoms.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Deliverable will be a final report with results that will provide the first comprehensive analysis of biomarkers of ocular vascular dysfunction resulting from spaceflight that are associated with development of SANS in astronauts.
These outcomes could help us understand the relationships between physiological and visual outcomes versus CSF biomarkers, leading to a better understanding of SANS mechanisms and development of personalized countermeasures to protect ocular health and performance.
Internal Customers:
Human Health Countermeasures
External Customers:
None