Last Published:  11/23/20 11:55:13 AM (Central)
Short Title: Supercomputer genomics
Responsible HRP Element:
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Aims:
This task will determine the feasibility of using novel bioinformatics tools on the NASA Ames supercomputer to address DNA mutation rate in spaceflight, both in astronauts and in supportive experimental systems.

Specific Milestones:
1. Setup remote access to the supercomputer and create a pilot account at the NASA supercomputer for running developed analytics tools and environment. Test installation options of basic tools and software needed for implementation of automated pipeline based on Toil (automated pipeline workflow tool).
2. Organize and test setup and installation of Docker virtual environment for running individual pipeline components. Order and configure basic node of Docker needed on a given operating system of the supercomputer.
3. Setup and test dynamic storage of 5-10 Terabytes for downloading GeneLab data needed for processing and running pipeline.
4. Create a tool for automated configuration of pipeline based on target data to run analyses. Preparation of data sources for analysis of oxidative stress response to spaceflight at the NASA ARC supercomputer. Collection of data for analysis of oxidative stress response to spaceflight for scaling up of the above tools.
5. Assess and validate supercomputer performance and improvement of pipeline based on a figure of merit relative to conventional computers (i.e.  increasing throughput of data processing by a factor equal to the number of machine processor cores). Testing analysis of oxidative stress response of selected samples to spaceflight.
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskSupercomputer genomics to help maintain core capability at ARC

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskSupercomputer genomics to help maintain core capability at ARC

RiskRisk of Radiation Carcinogenesis
You are here!TaskSupercomputer genomics to help maintain core capability at ARC

RiskRisk of Spaceflight Induced Cardiovascular Disease
You are here!TaskSupercomputer genomics to help maintain core capability at ARC