Task Mapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification
Last Published:  07/30/20 02:45:15 PM (Central)
Short Title: Mapping peripheral immune signatures
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Aim 1. Blood-based biomarker signature to improve biodosimetry in response to simulated GCRs and their components.
Aim 2. Define blood-based biomarkers of individual susceptibility to simulated GCRs and their components.
Aim 3. Evaluate relative biological effectiveness (RBE) between biomarkers and dose rate effects.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskMapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification

RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskMapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification

RiskRisk of Radiation Carcinogenesis
You are here!TaskMapping peripheral immune signatures of mouse and human responses to space radiation for biomarker identification