Task Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.
Last Published:  11/23/20 11:55:12 AM (Central)
Short Title: Cardiovascular responses to simulated spaceflight
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Aim 1. Determine radiation dose-dependence of measures of cardiovascular performance in crew age-matched female and male mice in an acute ‘five-ion GCR simulation’ exposure model.
Aim 2. Determine effects of acute ‘five-ion GCR simulation’ exposure singly and in combination with simulated microgravity on cardiovascular performance measures in crew age-matched male and female mice, mimicking deep space missions.
Aim 3. Determine whether cardiovascular changes induced by GCR or in combination with HU correlate with specific and measurable behavioral, neuromotor and immune outcomes.
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