HRR - Task - Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures

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Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Diaz Artiles, Ana

Short Title: Grav-Induced CV Changes - Lab

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1:
To generate dose-response relationships between cardiovascular and ocular parameters as a function of changes in the gravitational vector.

Specific Aim 2:
To develop a computational model to predict cardiovascular and ocular variables due to changes in the gravitational vector.

Specific Aim 3:
Identify, explore, and simulate the effects of countermeasures (i.e. Lower Body Negative Pressure, exercise) on cardiovascular and ocular parameters using both experimental results and modeling techniques.

Resources (Other)

Deliverables (3)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Dose-response relationships between cardiovascular and ocular parameters as a function of changes in the gravitational vector

Internal Customers:
Human Health Countermeasures
External Customers:
None

Category: Technology or Tool
Subcategory: Computational Models or Simulations

Description:

A validated numerical model capable of predicting CV and ocular responses due to changes in

the gravitational vector.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:
TBD

Internal Customers:
None External Customers:
None

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-103: Determine whether ground-based induced fluid shifts lead to ocular manifestations.

SANS-301: Develop and test mechanical countermeasures in the laboratory.

SANS-303: Test the efficacy of AG (centrifugation)-induced fluid shift versus other mechanical countermeasures.

Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Related Tasks (208)

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.