Short Title:
SANS CM Bedrest - Exercise
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Specific Aim 1: To determine if donning veno-occlusive thigh cuffs during and for 120 minutes
after daily aerobic exercise can be used to (a) reverse headward fluid shift from bed rest for a
sustained period of time and (b) prevent ocular structural and functional changes from
developing at the end of bed rest.
Specific Aim 2: To determine the role of altered ocular vasculature in the development of optic disc
edema in this spaceflight analog.
Ground Analog Resources
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Ground-Based Flight Analogs
- Bedrest [e.g., envihab, other bedrest facilities]
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| Number of Subjects
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48
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Category:
Countermeasure
Subcategory:
Clinical Procedure/Prescription
Description:
The primary deliverable for this investigation will be a report that details the effects of exercise and occlusive venous thigh cuffs as a countermeasure to SANS on healthy volunteers in a strict 6 degree head-down bedrest model. Recommendations will be made regarding the potential usefulness of evaluated countermeasures as a SANS countermeasure and the next steps in countermeasure development, if warranted.
Internal Customers:
None
External Customers:
None