Short Title:
SANS CM Bedrest - B complex
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Strict 6-degree HDT bed rest will be utilized to test countermeasures against SANS. The overall bedrest study consists of 4 groups of 12 subjects. The goal of this study is to better understand the role of the 1-C pathway in SANS in a bedrest model.
Specific Aims
1. Determine one-carbon pathway SNP profiles in all subjects, and assess whether
individuals with 3-4 risk alleles for MTRR A66G and SHMT1 C1420T
polymorphisms have greater ΔTRT during and after 30-d HDT bed rest.
2. Determine whether subjects with 3-4 risk alleles exhibit differences in biomarkers of
endothelial function, compared to subjects with 0-2 risk alleles.
3. Determine viscoelastic properties of the posterior sclera before, during, and after bed
rest, and determine influence of genetics and B-vitamin status on these properties and
any changes due to bed rest.
Ground Analog Resources
Ground-Based Flight Analogs
- Bedrest [e.g., envihab, other bedrest facilities]
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Number of Subjects
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48
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Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence of the role of the 1-C pathway in SANS in a strict head-down bed rest model.
Internal Customers:
None
External Customers:
None