HRR - Task - B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)

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B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Zwart, Sara

Short Title: SANS CM Bedrest - B complex

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:
Strict 6-degree HDT bed rest will be utilized to test countermeasures against SANS. The overall bedrest study consists of 6 groups of 12 subjects. For this study, the 12 subjects in the non-mechanical countermeasure group will receive a daily nutritional countermeasure while the 12 subjects in the control group will receive a placebo.

Specific Aims

1. Determine whether provision of a non-mechanical countermeasure: supplementation
with bioactive B-vitamins: L-methyltetrahydrofolate (5-MTHF), pyridoxine,
methylcobalamin, and riboflavin; prevents or mitigates SANS pathology (significant
ΔTRT) compared to a placebo controlled group.

2. Determine one-carbon pathway SNP profiles in all subjects, and assess whether
individuals with 3-4 risk alleles for MTRR A66G and SHMT1 C1420T
polymorphisms have greater ΔTRT during and after 30-d HDT bed rest.

3. Determine whether subjects with 3-4 risk alleles exhibit differences in biomarkers of
endothelial function, compared to subjects with 0-2 risk alleles.

4. Determine viscoelastic properties of the posterior sclera before, during, and after bed
rest, and determine influence of genetics and B-vitamin status on these properties and
any changes due to bed rest.

Resources (Ground Analog)