Task B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: SANS CM Bedrest - B complex
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Strict 6-degree HDT bed rest will be utilized to test countermeasures against SANS.  The overall bedrest study consists of 4 groups of 12 subjects.  The goal of this study is to better understand the role of the 1-C pathway in SANS in a bedrest model.    

Specific Aims


1. Determine one-carbon pathway SNP profiles in all subjects, and assess whether
individuals with 3-4 risk alleles for MTRR A66G and SHMT1 C1420T
polymorphisms have greater ΔTRT during and after 30-d HDT bed rest.

2. Determine whether subjects with 3-4 risk alleles exhibit differences in biomarkers of
endothelial function, compared to subjects with 0-2 risk alleles.

3. Determine viscoelastic properties of the posterior sclera before, during, and after bed
rest, and determine influence of genetics and B-vitamin status on these properties and
any changes due to bed rest.

Mappings
RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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