Short Title:
SANS CM Bedrest - B complex
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Strict 6-degree HDT bed rest will be utilized to test countermeasures against SANS. The overall bedrest study consists of 6 groups of 12 subjects. For this study, the 12 subjects in the non-mechanical countermeasure group will receive a daily nutritional countermeasure while the 12 subjects in the control group will receive a placebo.
Specific Aims
1. Determine whether provision of a non-mechanical countermeasure: supplementation
with bioactive B-vitamins: L-methyltetrahydrofolate (5-MTHF), pyridoxine,
methylcobalamin, and riboflavin; prevents or mitigates SANS pathology (significant
ΔTRT) compared to a placebo controlled group.
2. Determine one-carbon pathway SNP profiles in all subjects, and assess whether
individuals with 3-4 risk alleles for MTRR A66G and SHMT1 C1420T
polymorphisms have greater ΔTRT during and after 30-d HDT bed rest.
3. Determine whether subjects with 3-4 risk alleles exhibit differences in biomarkers of
endothelial function, compared to subjects with 0-2 risk alleles.
4. Determine viscoelastic properties of the posterior sclera before, during, and after bed
rest, and determine influence of genetics and B-vitamin status on these properties and
any changes due to bed rest.
Ground Analog Resources
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Ground-Based Flight Analogs
- Bedrest [e.g., envihab, other bedrest facilities]
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| Number of Subjects
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72
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Category:
Countermeasure
Subcategory:
Protocol
Description:
Development and testing of an efficient and safe non-mechanical countermeasure against SANS.
Internal Customers:
None
External Customers:
None