HRR - Task - CVD Integrated Flight Countermeasure Study on ISS

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- CVD-203
  - CVD

CVD Integrated Flight Countermeasure Study on ISS

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: TBD

Short Title: CVD Integrated CM - ISS

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Planned-Funded - Task expected to be within budget

Procurement Mechanism(s):

TBD

Aims:

Countermeasure efficacy tests in ISS astronauts through the ISS Standard Measures Study (e. g. 1YMP) and retrospective analysis of medical records.

Resources (Flight)

Flight Resources

Number of Subjects

Deliverables (1)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:
Countermeasures and procedures against spaceflight-induced changes in the cardiovascular system that can lead to later disease. Understanding of which countermeasures are operationally-feasible during exploration missions within the context of the DRM.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-203: Test countermeasures on the ISS against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

CVD Integrated Flight Countermeasure Study on ISS

Related Tasks (114)

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capacity, and Risk of Cardiac Arrhythmias (ICV-Bungo/Levine, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Animal radiation study (Radiation Pilot-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Bracelet Investigation (Brazlet Dulchavsky, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs, SDTO 17011 U/R (Braslet-M -- Duncan, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Identification of cardiometabolic vulnerabilities caused by effects of synergistic stressors that are commonly encountered during space missions (Cardiometabolic Vulnerabilities-Shea, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of emotional stress on the cardiovascular system (Stress and CV Health-TBD, Planned)

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	Risk of Spaceflight Induced Cardiovascular Disease

Determining the Effect of Space Flight on the Incidence of Cardiovascular Risk Factors and Disease (CV Data Mining-Barstow, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Temperature Regulatory and Cardiovascular Responses to Exercise During Long-Duration Spaceflight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Early Markers of Space-Radiation Induced Human Cataractogenesis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Estrogen on Cataract Induction After Exposure to High LET Radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Human endothelial cells in 2-D and 3-D systems; non-cancer effects and space-related radiations

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms, early events, and dose dependence of radiation-induced atherosclerosis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Ionizing Radiation and its Effects on Cardiovascular Function in the Context of Space Flight

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

A Metabolomics and Mouse Models Approach to Study Inflammatory and Immune Responses to Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Oxidative Stress and Skeletal Health with Low Dose, Low LET Ionizing Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Non-Invasive Early Detection and Molecular Analysis of Low X-ray Dose Effects in the Lens

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Cardiovascular Imaging and Strategies to Mitigate the Risk for Cardiac Events in Astronauts During Prolonged Spaceflight (Cardiac Risk-Imaging -- Levine, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Impact of Long Duration Space Flight On Cardiac Structure and Function (Long Duration-Cardiac -- Thomas, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Evaluation of Space Radiation-induced Myocardial and BM-derived EPC Damage and Assessment of Associated Long-term Degenerative Cardiovascular Risks

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Intestinal Microflora on High-LET Radiation Mediated Toxicity and Genomic Instability

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Lee, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Molecular mechanisms underlying heart failure and arrhythmias in astronauts (1-year NSBRI Postdoctoral Fellowship) (Molecular Arrhythmias-Gershovich/Werhans, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effect of Space Radiation on degenerative tissue disease, genetic Instability and Oxidative DNA Damage in Ataxia Telangiectasis Deficient Mice

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Precise Assessment of Prevalence and Progression of Lens Opacities in Astronauts as a Function of Radiation Exposure During Space Flight and Development of Improved Routine Clinical Assessment of Ocular Lens Status

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mechanisms of Ocular Cataracts

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	Risk of Spaceflight Induced Cardiovascular Disease

Low Dose Radiation Cataract

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	Risk of Spaceflight Induced Cardiovascular Disease

Echocardiographic Assessment of Cardiovascular Adaptation and Countermeasures in Microgravity (Cardio Adaptation-Thomas, Completed)

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	Risk of Spaceflight Induced Cardiovascular Disease

Proteomic Profiling of Human Heart Tissue Exposed to Microgravity (Proteomic Heart-Bowles, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Microgravity Associated Compartmental Equilibration (MACE) [FLUID SHIFTS / DULCHAVSKY / ACTIVE]

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	Risk of Spaceflight Induced Cardiovascular Disease

Fluid Distribution before, during and after Prolonged Space Flight-NNX13AJ12G [FLUID SHIFTS / HARGENS / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance [FLUID SHIFTS / STENGER / ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Targeting NO/IKK Signaling to Counteract Hemodynamic Flow-Dependent Endothelial Dysfunction and Vascular Damage after Space Radiation (Endothelial Dysfunction SR-Natarajan, Active)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Recovery of Functional Performance Following Long Duration Space Flight (Reschke)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed)

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	Risk of Spaceflight Induced Cardiovascular Disease

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Effects of Space Radiation on Stem Cells and Vascular and Cardiac Disease

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT/ACTIVE]

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE/ACTIVE]

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	Risk of Spaceflight Induced Cardiovascular Disease

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

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	Risk of Spaceflight Induced Cardiovascular Disease

Combined Effects of Space Radiation and Microgravity on the Function of Human Capillaries and the Endothelial Barrier: Implications for Degenerative Disorders

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	Risk of Spaceflight Induced Cardiovascular Disease

Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening

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	Risk of Spaceflight Induced Cardiovascular Disease

Determination of risk for and occurrence of heart disease from space radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Long-Term Effect of Space Radiation on Cardiomyocyte Turnover

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	Risk of Spaceflight Induced Cardiovascular Disease

Space Radiation Risk Assessment Project

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	Risk of Spaceflight Induced Cardiovascular Disease

2022 NSCOR: CVD/Late CNS clinical MCM Assessment

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2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

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	Risk of Spaceflight Induced Cardiovascular Disease

Integrated Cardiovascular (ICV) 2.0: Assessing the Risk for Atrial Fibrillation in Astronauts During Long Duration Spaceflight [INTEGRATED CARDIOVASCULAR 2/LEVINE/ACTIVE]

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	Risk of Spaceflight Induced Cardiovascular Disease

Biomarker Assessment for Identifying Heightened Risk for Cardiovascular Complications During Long-Duration Space Missions [IMAGING AND OMICS - CV RISK/LINDNER/ACTIVE]

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	Risk of Spaceflight Induced Cardiovascular Disease

Center for Research on Cardiac and Vascular Effects of Space Radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Million Worker and Veteran Study

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	Risk of Spaceflight Induced Cardiovascular Disease

Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles

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	Risk of Spaceflight Induced Cardiovascular Disease

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

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	Risk of Spaceflight Induced Cardiovascular Disease

Mars 600/900 Simulation I: Large Animal Chronic Studies

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	Risk of Spaceflight Induced Cardiovascular Disease

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

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	Risk of Spaceflight Induced Cardiovascular Disease

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

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	Risk of Spaceflight Induced Cardiovascular Disease

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

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	Risk of Spaceflight Induced Cardiovascular Disease

Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)

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	Risk of Spaceflight Induced Cardiovascular Disease

Gravitational dose and multi-system physiologic response

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	Risk of Spaceflight Induced Cardiovascular Disease

Center for Medical Countermeasures II – Cross Risk

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	Risk of Spaceflight Induced Cardiovascular Disease

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Mars 600/900 Simulation II: Large Animal Chronic Studies

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	Risk of Spaceflight Induced Cardiovascular Disease

Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)

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	Risk of Spaceflight Induced Cardiovascular Disease

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (OPHTHALMIC MODELING CHANGES 2)

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	Risk of Spaceflight Induced Cardiovascular Disease

Effects of chronic and single-dose charged particle exposure on cardiac function and structure in multiple animal models

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	Risk of Spaceflight Induced Cardiovascular Disease

Degenerative Cardiovascular Disease Risks Due to Single HZE or Mixed Ion Radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Tissue Sharing Project-Effects of space radiation on the cardiac mitochondrial stress response

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	Risk of Spaceflight Induced Cardiovascular Disease

Attenuation of Space Radiation-induced Pro-oxidant and Fibrotic Signaling in the Heart by Nutritional and Genetic Interventions: Adventures in Tissue Sharing

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	Risk of Spaceflight Induced Cardiovascular Disease

2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

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	Risk of Spaceflight Induced Cardiovascular Disease

Galactic Cosmic Ray Simulator and Mitigation Project

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	Risk of Spaceflight Induced Cardiovascular Disease

GCR Simulation Dose Rate Studies

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	Risk of Spaceflight Induced Cardiovascular Disease

Multi-Model Ensemble Risk Assessment

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	Risk of Spaceflight Induced Cardiovascular Disease

Inter-Agency Medical Countermeasures Studies

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	Risk of Spaceflight Induced Cardiovascular Disease

Contracted Study CM Validation II (Cross Risk)

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	Risk of Spaceflight Induced Cardiovascular Disease

Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

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	Risk of Spaceflight Induced Cardiovascular Disease

Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Imaging and Serum Biomarkers to Predict and Identify Early Cardiac Injury from Radiation Exposure

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	Risk of Spaceflight Induced Cardiovascular Disease

Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

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	Risk of Spaceflight Induced Cardiovascular Disease

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

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	Risk of Spaceflight Induced Cardiovascular Disease

A determination of bioactive proteins secreted by the human vasculature in response to low dose space radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Predictive Biomarkers for Space Radiation Induced Cancer and Cardiovascular Injury Risk Assessment

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	Risk of Spaceflight Induced Cardiovascular Disease

Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits

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	Risk of Spaceflight Induced Cardiovascular Disease

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	Risk of Spaceflight Induced Cardiovascular Disease

Telomeres and the One Year Mission Project

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	Risk of Spaceflight Induced Cardiovascular Disease

Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease, and the effectiveness of a countermeasure

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	Risk of Spaceflight Induced Cardiovascular Disease

Countermeasures to Radiation Induced Cardiomyopathy

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	Risk of Spaceflight Induced Cardiovascular Disease

Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Downs)

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	Risk of Spaceflight Induced Cardiovascular Disease

Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation.

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	Risk of Spaceflight Induced Cardiovascular Disease

Effects of Spaceflight Durations up to One Year in Low Earth Orbit on Cardiovascular Structure and Function in Astronauts

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	Risk of Spaceflight Induced Cardiovascular Disease

Cardiovascular Disease Data Mining Phase II with Cooper Clinic

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Ovarian cancer and space radiation

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	Risk of Spaceflight Induced Cardiovascular Disease

Supercomputer genomics to help maintain core capability at ARC

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	Risk of Spaceflight Induced Cardiovascular Disease

Assessment of galactic cosmic ray dose rate effects on endothelial function

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	Risk of Spaceflight Induced Cardiovascular Disease

The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract

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	Risk of Spaceflight Induced Cardiovascular Disease

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

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	Risk of Spaceflight Induced Cardiovascular Disease

The impact of human spaceflight on clonal hematopoiesis

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Characterization of Jugular Venous Blood Flow during Acute Fluid Shifts

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Coronary Anatomy and Physiology During 1 Year in Space - ISS

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Rat Radiation + ISS Flight

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	Risk of Spaceflight Induced Cardiovascular Disease

CVD Monitoring on Deep Space Gateway

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	Risk of Spaceflight Induced Cardiovascular Disease

Rodent Lunar Stays

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Rat Countermeasure Radiation + ISS Flight

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-203: Test countermeasures on the ISS against the spaceflight-induced changes in the cardiovascular system of importance for development of disease.

CVD Integrated Flight Countermeasures Study for Deep Space Gateway and Lunar

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	Risk of Spaceflight Induced Cardiovascular Disease

Development for Rodent Lunar Stays - Lab

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Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight

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	Risk of Spaceflight Induced Cardiovascular Disease

Thrombosis Countermeasures - ISS

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	Risk of Spaceflight Induced Cardiovascular Disease

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