HRR - Task - Deep Space Crew Microbiome Standard Measure (Flight)

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Deep Space Crew Microbiome Standard Measure (Flight)

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: TBD

Short Title: Deep Space Crew Microbiome

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Planned-Funded - Task expected to be within budget

Procurement Mechanism(s):

TBD

Aims:

Collect biological samples from crew members at designated collection time points pre-flight, in-flight throughout deep space mission and post-flight that will include gut, skin and saliva microbiomes for subsequent evaluation of changes in concentration, diversity and/or responses of medically significant microorganisms.

Resources (Flight)

Flight Resources

Number of Subjects

Deliverables (1)

Category: Standard
Subcategory:

Description:
An archive of biological samples that can be analyzed for ‘omics work.

Internal Customers:
None External Customers:
None

Mappings

Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Deep Space Crew Microbiome Standard Measure (Flight)

Related Tasks (31)

SWAB E-049 A Comprehensive Characterization of Microorganisms and Allergens in Spacecraft Environment

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

High Dimensional Biology to Understand the Functional Response of Salmonella to Long-Term Multigenerational Growth in the Chronic Stress of Microgravity

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Data Mining

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

HHC, NASA Flight Experiment Research Contributing to Microbial Risk Modeling

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Microbial Risk Assessment and Integration

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Development of Spaceflight Foods with High Microbial Concentrations

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Free Water Events on Mir and ISS

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Study of the impact of long-term space travel on the astronaut's microbiome

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Efficacy of Antimicrobials on Bacteria Cultured in a Spaceflight Analog

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Next Generation Microbiology Requirements

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Delivery of Probiotics in the Space Food System

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Evaluating the Spaceflight Infectious Disease Risk Potential of Pathogenic and Commensal microorganisms using Caenorhabditis elegans as a Human Surrogate Model for Infection

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Quantitative Risk Assessment Study for Surface Risk

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Fluid Shift Associated Lymphostasis of the Gut Induces Inflammation and Microbial Intolerance (NSBRI-Cromer)

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Baseline Microbial Assessment of Fresh Produce

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Spaceflight-Induced Changes in Microbial Virulence and the Impact to the Host Immune Response

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Culture-based Environmental Monitoring of Crop-based Space Food Systems

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

MicroHost Countermeasure Validation

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Quantitative Microbial Risk Assessment: Exploring the Microbiome at the International Space Station to Develop Food Production Systems

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Space Food System Microbial Requirements Development

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Molecular-based Environmental Microbial Monitoring of Cropped Based Food System

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Produce Safety Methods

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Retrospective Radiation Effect on Microbiome in irradiated populations

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Microhost retrospective evaluation of incidence and severity ISS/Analog

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Bacillus spore probiotics: evaluation of survival and efficacy after exposure to deep-space radiation simulating long-duration human exploration missions

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-102: Evaluate whether deep-space radiation has an additive or synergistic effect with weightlessness/isolation/confinement on microbial types, numbers, and virulence.

Pilot Co2 and hypoxia spaceflight relevant microorganisms

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight 2 (HRP Funded)

Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions

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PRRs (1)

This task can be found in the following Paths to Risk Reduction.

Microhost Path to Risk Reduction

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