Short Title:
IJV Endothelium Role-Rodent
Responsible HRP Element:
Human Health Countermeasures
Funding Status:
Active - Currently funded and in progress
Procurement Mechanism(s):
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Aims:
Aim I: Recapitulate the Abnormal IJV flow patterns observed in crew members
aboard the ISS in an isolated, perfused vein organ culture system and determine if
there are changes in endothelial gene expression using RNA sequencing.
Aim II: Confirm that any changes in candidate genes identified in Aim I are
expressed at the protein level.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterize changes in internal jugular vein endothelial gene expression using a rodent model that replicates abnormal flow patterns observed in astronauts on the ISS
Internal Customers:
None
External Customers:
None