HRR - Task - Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

NASA Logo Human Research Roadmap HRP Exploration Data

Evidence MDRP Risks Gaps Tasks Reports

Explore Search

- CVD-101
  - CVD

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Taylor, W. Robert

Short Title: IJV Endothelium Role-Rodent

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim I: Recapitulate the Abnormal IJV flow patterns observed in crew members
aboard the ISS in an isolated, perfused vein organ culture system and determine if
there are changes in endothelial gene expression using RNA sequencing.

Aim II: Confirm that any changes in candidate genes identified in Aim I are
expressed at the protein level.

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

Related Tasks (112)

Print View...

Risk Approach Plans (1)

NASA Developer: Daniel Febus Responsible NASA Official: Susan Torney Contact HRP for a 508 compliant PDF Budgets, Strategic Plans, and Accountability Reports Equal Employment Opportunity Data Posted Pursuant to the No Fear Act Information-Dissemination Policies and Inventories Freedom of Information Act President's Management Agenda Privacy Policy & Important Notices Inspector General Hotline Contact HRP Human Health and Performance DIR Johnson Space Center USA.gov ExpectMore.gov

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.