HRR - Task - Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

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Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Taylor, W. Robert

Short Title: IJV Endothelium Role-Rodent

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim I: Recapitulate the Abnormal IJV flow patterns observed in crew members
aboard the ISS in an isolated, perfused vein organ culture system and determine if
there are changes in endothelial gene expression using RNA sequencing.

Aim II: Confirm that any changes in candidate genes identified in Aim I are
expressed at the protein level.

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight (Taylor)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.