HRR - Task - Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight

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Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Taylor, W. Robert

Short Title: TBD

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim I: Recapitulate the Abnormal IJV flow patterns observed in crew members
aboard the ISS in an isolated, perfused vein organ culture system and determine if
there are changes in endothelial gene expression using RNA sequencing.

Aim II: Confirm that any changes in candidate genes identified in Aim I are
expressed at the protein level.

Resources (None Listed)

Deliverables (1)

Category: Study Results
Subcategory:

Description:
Characterize changes in internal jugular vein endothelial gene expression using a rodent model that replicates abnormal flow patterns observed in astronauts on the ISS

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Potential Role of the Endothelium in Internal Jugular Venous Thrombosis due to Abnormal Venous Flow Patterns During Spaceflight

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