HRR - Task - Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight

Spaceprint: Development and Validation of a Tool to Predict, Evaluate, and Mitigate Excessive Workload Effects

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Integrated Cognitive Assessment: Combining Measurement, System, and Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Cognitive Performance and Stress in a Simulated Space Environment

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Transition Actiwatch Protocol to Medical Operations

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Techwatch for Sleep Monitoring Technologies for Long Duration Spaceflight

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Optimizing Light for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Blue Light for Enhancing Alertness in Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Physiologically-Based Modeling of Sleep-Wake Scheduling and the Effects of Pharmaceuticals (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Individualized Fatigue Meter for Space Exploration (SBIR Phase II)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Countermeasures to Neurobehavioral Deficits from Cumulative Sleep Deprivation During Space Flight: Dose-Response Effects of Recovery Sleep Opportunities

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Stress Detection System

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Sleep Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Characterize Workload on the International Space Station (ISS) (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

rVisual Impairment and Intracranial Pressure Project Data Mining

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals [SD-OCT ANALYSIS/PASS/COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Prospective Observational Study of Ocular Health in ISS Crews (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Replacement Lighting for Research and Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mathematical Modeling of Circadian/Performance Countermeasures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

A Model of Circadian Disruption in the Space Environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of a User Interface for the PVT SelfTest (PST)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight? [VIIP PHARM/WOTRING]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Selection Studies Retrospective

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Net Habitable Volume Community of Practice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

SD/Development of in-flight fundoscopy

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Fundoscopy Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Development of in-flight diagnostic OCT

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Diagnostic OCT Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

ICP Tech Search (Innocentive, Yet To Come) COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Microgravity on Intracranial Pressure [MICROGRAVITY ICP/LEVINE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer [CCFP DATA MINING/EBERT/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Upgrade Visual Acuity Software and In-flight Tonometer

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Non-invasive ICP device purchase & evaluation [VITTAMED ICP DEVICE EVALUATION/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight (Fuller)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.

Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Retrospective Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics [MR-ICP CSF DYNAMICS RETROSPECTIVE/ALPERIN]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Brain Gene Expression Signatures from Cerebrospinal Fluid Exosome RNA Profiling [CSF EXOSOME GROUND/ZANELLO]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Microgravity Associated Compartmental Equilibration (Dulchavsky)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Fluid Distribution before, during and after Prolonged Space Flight (Hargens)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution (Roberts)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Evaluation of Hindlimb Suspension as a Model to Study Ophthalmic Complications in Microgravity: Ocular Structure and Function and Association with Intracranial Pressure (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Ultra-Short Light Pulses as Efficient Countermeasures for Circadian Misalignment and Objective Performance and Subjective Alertness Decrements

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The ISS Dynamic Lighting Schedule: An in-flight lighting countermeasure to facilitate circadian adaptation, improve sleep and enhance alertness and performance on the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Markers of Susceptibility to Neurobehavioral Decrements in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound [ULTRASOUND ICP/DENTINGER]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement [NON-INVASIVE ICP GROUND COMPARISON/WILLIAMS/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

A gene expression and histological approach to the study of cerebrospinal fluid production and outflow in rats (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Testing Mechanical Countermeasures for Cephalad Fluid Shifts [MECHANICAL COUNTERMEASURES - MARKETED DEVICES/STRANGMAN]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Venous Congestion Countermeasure Study (Marshall-Goebel)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Vehicle NHV and Habitability Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Long-duration Microgravity on Fine Motor Control Skills

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Effects of Long-Duration Spaceflight on Training Retention

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Analog investigation of team resilience over time

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Understanding Key Components of Successful Autonomous Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Investigate shifts in team cognitive processes over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Investigate shifts in team motivation and morale over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Developing and Validating Sensor-based Measurement Strategies for Team Member Selection

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Real-Time Neurocognitive Assessment Toolkit (Cognition) for Space Flight Fatigue (ISS-12) (NSBRI)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Microgravity-driven Optic Nerve/Sheath Remodeling Simulator [OPHTHALMIC CHANGES MODELING/ETHIER]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mapping by VESGEN of Blood Vessels in the Human Retina for Improved Understanding of Visual Impairments and Increased Intracranial Pressure (Parsons-Wingerter)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Role of the Cranial Venous Circulation in Microgravity-Associated Visual Changes [CRANIAL VENOUS CIRCULATION/BUCKEY]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Long Duration Spaceflight on Venous and Arterial Compliance in Astronauts [VASCULAR COMPLIANCE/PLATTS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

STARwatch to Deliver Objective Sleep Measures for Spaceflight Operations (SBIR Phase 2)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Lighting Protocols for Exploration - HERA Campaign

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Validation of model predictions of alertness, performance, and sleepiness

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Diet as a sleep/circadian countermeasure (Research Requirements)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Psychomotor Vigilance Test (PVT) on ISS (Reaction Self-Test on ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight (ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Metrics and Methods for Real-Time Task Performance Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Preventing Secondary Brain Injury by Early Detection of Cerebral Bleeding and Edema [CEREBROTECH/LEVINSON/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Acute and long term outcomes of simulated deep space radiation exposure on latent viral CNS infection & CNS pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Digital Astronaut: VIIP Modeling

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evaluation of the validity, acceptability and usability of bio-mathematical models to predict fatigue in an operational environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Workload and Scheduling Tools for Long Duration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Assess Glymphatic Changes for Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Future Vehicle Environment (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development of a Software and User Interface to Support Scenario Modeling of Astronaut Schedules to Aid in the Selection of Fatigue Countermeasures within the Behavioral Health and Performance Dashboard (BHP-DS)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Post-Mission Behavioral Health Conditions Assessment (RR+Datamining)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Influence of Exercise Modality on Cerebral-Ocular Hemodynamics and Pressures [EXERCISE MODALITY/SCOTT]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.

Social, Family, and Behavioral Health Support NSCOR

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Astronaut Exploration Factors (Data Mining & Whitepaper)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meaningful Work for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Biomarkers as Predictors of Resiliency and Susceptibility to Stress in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing the Impact of Chronic Sleep Restriction on Sleep and Performance-Associated Regional Brain Activation Using Near-Infrared Spectroscopy (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Monitoring Technologies COTS and NASA Tools Evaluation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Cognitive Performance and Crew Cohesion during Confinement in NASA's Human Research Program Human Exploration Research Analog (HERA)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Radiation Exposures in Space and the Potential of Central Nervous System Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

HZE particle exposure-induced improvement of pattern separation in mature mice: alterations in mission-relevant behaviors and neural circuitry

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Family Training and Support Research Requirements

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Software Enabled Therapeutics for Psychiatry, Neurology, and Pain

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Cognition Validation Study in High Performing Healthy Controls at Penn

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cognitive Bias and Decision Making Training (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NASA Specialized Center of Research on Carcinogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Late CNS Risk Modeling

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

2022 NSCOR: CVD/Late CNS clinical MCM Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Team and Sleep Preliminary Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Analog Team/Behavioral Medicine Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Cognitive Assessment and Prediction to Promote Individualized Capability Augmentation and Reduce Decrement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Lighting as a Cognitive and Behavioral Health Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Personality and biological predictors of resiliency to chronic stress among high-achieving adults

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evaluation of an Impedance Threshold Device as a Vision Impairment and Intracranial Pressure (VIIP) Countermeasure [IMPEDANCE THRESHOLD COUNTERMEASURE/EBERT]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Validation of a Cephalad Fluid Shift Countermeasures [FLUID SHIFT COUNTERMEASURE/MACIAS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Use of Hypnotic and Alertness Medications in Military Populations (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sleep electroencephalography and near-infrared spectroscopy measurements for spaceflight and analogs

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study (Smith)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Environmental Factors Associated with Sleep Deficiency During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Behavioral Issues Associated with Long Duration Space Missions: Review and Analysis of Astronaut Journals - Extension and ISS-12

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Hadron-induced impairment of Executive Function:role of perturbed neurotransmission and the exacerbating impact of sleep deprivation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

STOP VIIP Study: Safe and Effective Countermeasures to Reduce Intracranial Pressure and Ameliorate VIIP in Astronauts [STOP VIIP/Levine]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Team State Lexical Analysis Software Refinement and Feasibility Testing

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Space-Radiation Induced Alterations on Toxic Protein Accumulation Associated with Neurodegenerative Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Mars 600/900 Simulation I: Large Animal Chronic Studies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Comparing Globe Distortions Following Head-Down Bed Rest to those Measured in Astronauts in Short and Long-Duration Spaceflights [Thirty-day CO2 Bedrest/ALPERIN/ACTIVE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.

Clinical Evaluation of the Newest Generation of a Non-Invasive ICP Meter (Vittamed) in Subjects Undergoing Invasive ICP Measurement [VITTAMED 2/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Optical System for Monitoring Net Ocular Blood Flow (Mujat)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

LumosTech Smart Sleep Mask for Circadian Realignment in Space and on Earth

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Real-Time Estimation of the Effects of a Simulated Long-Duration Exploration Mission on Flight Performance, Workload, and Situation Awareness

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Quantifying and Predicting Operationally-Relevant Performance in a Long-Duration Spaceflight Analog

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Center for Medical Countermeasures II – Cross Risk

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NSCOR #2: Acute CNS-Risk Modeling and CM Validation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mars 600/900 Simulation II: Large Animal Chronic Studies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Non-Pharm Treatments Verification and Validation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BHP Radiation CNS Standard Measures Table RR

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Cognition Longitudinal Validation Study in High-Performing Healthy Controls at Penn

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

NASA's Behavioral Core Measures (BCM) Cognition Battery vs. WinSCAT: Validation, Norming, and Intra-individual Differences Across Cognitive Domains of Two Spaceflight Cognitive Assessment Tools in Higher Functioning Adults

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Increasing Cognition Administration Order Flexibility

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of +Gz and -Gz induced fluid shifts on ocular and cerebral parameters during simulated Orion re-entry.

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Integrated Flight Countermeasure Studies

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Spaceflight Habitability Acceptability Questionnaire (SHAQ) Development and Validation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The Fine Motor Skills and Cognition Test Batteries: Normative Data and Interdependencies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

ISS HRP Spaceflight Exploration Measures (HFBP) for Gateway

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Generalizability of Operational Feasibility and Acceptability of HFBP Exploration Measures in NEK

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

HFBP Thresholds for Health & Operational Performance Permissible Outcome Limit (POL)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Identification and Validation of HFBP Exploration Measures in HERA for Transport

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Testing of Next Generation of Monitoring Tools for Deep Space & Planetary Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

HFBP Exploration Measures in HERA for Mars

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

ISS HRP Spaceflight Exploration Measures (HFBP) for Mars Fly-By

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Automated Transcription Maturation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Automated Video Analysis Software Maturation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Quantification of Response to Virtual Reality based Sensory Stimulation for Relaxation and Therapeutic Release in ICE

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual and Team Problem-Solving Skills Training for Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Galactic Cosmic Ray Simulator and Mitigation Project

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

GCR Simulation Dose Rate Studies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Multi-Model Ensemble Risk Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Inter-Agency Medical Countermeasures Studies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Contracted Study CM Validation II (Cross Risk)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Partnership with Dept of Defense to Inform Expeditionary Skills Training for Astronauts

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sex- and Apo E-specific late CNS and cardiovascular effects of space radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Quantitative Imaging and Biofluid Biomarkers Predictive of Cognitive Toxicity and Cerebro-/Cardiovascular Pathologies following Brain Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Effects of Artificial Gravity on Structural and Functional Plasticity During Head-Down Tilt Bed Rest

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Does Intermittent or Continuous Artificial Gravity Counteract Long Duration Bed Rest Induced Neurocognitive Declines?

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Adaptive Stress Training for Hazardous Conditions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Simulation-based Countermeasure Development to Mitigate Team and System Vulnerabilities During Medical Event Management on Long Duration Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determination/Development of standardization of both Research Facility (e.g., volume, lighting, sound, etc.) & Rodent type to increase reliability & validity of translational research yields related to operational performance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Central Nervous System, Behavioral Medicine, and Sensorimotor (CBS) Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Research Review: Neurobehavioral Biomarkers Performance/Pathway

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

CBS Operational Performance Measures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Integrated CNS/BMed/SM (CBS) POL/PEL Review and Standard Update

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Determine & Validate CNS/BMed/SM (CBS) relevant operational measures for integrated POLs and identify Research Measures for EM missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

CBS Integrated Risk inflight human monitoring (ISS & Orion DSLOP) for direct and synergistic effects of Acute CNS/BMed/SM (CBS) impacts to measures from which POLs are derived

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

CBS VNSCOR #1: Mechanisms of radiation-induced changes in sustained attention and social processing

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

SHARE/[TBD] GCRsim Exposure Response Study (NRA)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

NHP CNS Radiation/Performance Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Research Review: NHP Model Brain Performance Pathways

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Acute CNS Stress Response, Cross-species Homology Study (NRA)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

CBS Brain Regions Functional Modular Structure & Connections of Relevance to Operationally-Relevant Performance (RFP)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Future research (NSCOR) -- potential topics include RBEs, Glial cell response, stress response, cross-species homology, animal mood/social/cognition, sleep/stress/cognition, neural plasticity, dose rate effect for multiple measures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.

Integration of Research Findings from ongoing research (11 NRAs, 1 NSCOR; including epigenetics, synaptic function, neurobehavioral, neuroproteome, behavior & neural circuitry, biomarkers, sleep deprivation, affect/social) to guide development of PELs

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders