Task Ophthalmic and intracranial structural changes in head-down tilt bedrest: potential countermeasures and comparison to SANS findings in astronauts (Martin)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: SANS CM Bedrest- OPTICS
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:


The objective of this study is to use non-invasive magnetic resonance imaging to quantify structural changes in the brain and eye that occur in prolonged 6 degree head down tilt bedrest (HDT) and understand if these alterations can be mitigated using countermeasures.

The central hypothesis is that ophthalmic and intracranial structural alterations will be similar in prolonged bed rest compared to long-duration astronauts with SANS, and these alterations will be reduced by countermeasures applied during HDT. We will test this hypothesis by a) quantification of ophthalmic and intracranial structural alterations in HDT subjects and ambulatory control subjects compared to pre-HDT (Aim 1), b) determination if countermeasures can prevent and/or reduce HDT-induced structural alterations (Aim 2), and c) comparison of structural alterations in HDT subjects to those already quantified in astronauts that developed SANS (Aim 3).


Countermeasures to be tested in this study will be implemented by the following tasks.

1) Mechanical and gravitational countermeasures to ocular changes during strict head-down tilt bedrest (Marshall-Goebel) (https://hrrcms.jsc.nasa.gov/Tasks/?i=2379).
(2) Exercise Countermeasure to Prevent Ocular Structural and Functional Changes in a Terrestrial Model of SANS - Bedrest (Huang) (https://hrrcms.jsc.nasa.gov/Tasks/?i=2502).
(3) B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)  (https://hrrcms.jsc.nasa.gov/Tasks/?i=2503).

Mappings
RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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