Task Recovery Timeline of Spaceflight-Induced Central Nervous System Changes
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS VNSCOR#3 Recovery Timeline of Spaceflight-Induced CNS Changes (Seidler)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

SA1: Determine the recovery timeline of spaceflight-induced ocular changes (e.g., signs of SANS such as optic disc edema) and changes in brain structure, function, and fluid shifts, measuring out to five years post flight. Aim 1a will comprise prospective assessments, while Aim 1b will leverage follow up testing on crewmembers who participated in the PI’s Neuromapping flight study and those crewmembers who have existing retrospective pre and post flight MRI scans.

 

SA2:
Determine the associations between spaceflight-induced brain and

ocular structural and fluid changes with ocular function, cognitive function, sleep

quality and quality of life
Mappings
RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
GapBMed-108: Given each crewmember will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., space radiation, altered gravity, isolation, altered immune, altered sleep) on crew health and/or CNS/ cognitive functioning to develop threshold limits and validate countermeasures for any identified adverse crew health and/or operationally-relevant performance outcomes.
You are here!TaskRecovery Timeline of Spaceflight-Induced Central Nervous System Changes

RiskRisk of Altered Sensorimotor/Vestibular Function Impacting Critical Mission Tasks
You are here!TaskRecovery Timeline of Spaceflight-Induced Central Nervous System Changes

RiskRisk of Injury and Compromised Performance Due to EVA Operations
You are here!TaskRecovery Timeline of Spaceflight-Induced Central Nervous System Changes

RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
You are here!TaskRecovery Timeline of Spaceflight-Induced Central Nervous System Changes