Task CBS Exposure of Male and Female Mice to 33-Particle Galactic Cosmic Radiation (GCR): Negative Impact on Translationally relevant Hippocampal-based Cognition and Prevention of GCR-induced Deficits by Acute Treatment with the Anti-inflammatory CDDO-EA
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS Sex Differences in GCR-induced Deficits and Prevention by Acute Treatment with CDDO-EA (Yun)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: The study will determine the effects of (1a) 33-particle GCR (33-GCR) on hippocampal dentate gyrus (DG) function (pattern separation) and prefrontal cortex (PFC) functions (cognitive flexibility, extinction of stimulus-response) in 6-month-old mature male C57BL/6J mice and (1b) CDDO-EA on 33-GCR-induced cognitive changes.

Aim 2: The study will also define DG neurogenesis and DG and PFC inflammation in female and male mice exposed to 33-GCR or Sham with and without CDDO-EA.

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