Task Understanding the Impact of Hypobaric Hypoxia and Confinement Stress on Intestinal Immunity and Host-Microbiome Interactions
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: CBS Impact of Hypoxia and Confinement on Intestinal Immunity (Torralba)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: Characterization of gut microbiota and immune profiles of Concordia and Neumayer crewmembers. 16S rRNA sequencing and mass spectrometry based meta-proteomic approaches will be employed to investigate both the microbial composition and host immune responsive proteins.


Aim 2: Global profiling of gut protein PTMs. Enrichment (e.g., antibody-based) and quantitative (e.g., chemical labeling) strategies will be utilized to examine protein acetylation and oxidation, which will be correlated to host metabolism and oxidative damage.


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