Task Understanding the Impact of Hypobaric Hypoxia and Confinement Stress on Intestinal Immunity and Host-Microbiome Interactions
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: CBS Impact of Hypoxia and Confinement on Intestinal Immunity (Torralba)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Factors and Behavioral Performance (HFBP) Element
Human Health Countermeasures (HHC) Element
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):

Aim 1: Characterization of gut microbiota and immune profiles of Concordia and Neumayer crewmembers. 16S rRNA sequencing and mass spectrometry based meta-proteomic approaches will be employed to investigate both the microbial composition and host immune responsive proteins.

Aim 2: Global profiling of gut protein PTMs. Enrichment (e.g., antibody-based) and quantitative (e.g., chemical labeling) strategies will be utilized to examine protein acetylation and oxidation, which will be correlated to host metabolism and oxidative damage.

Resources (None Listed)