HRR - Task - Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function

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Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Seidler, Rachael

Short Title: Glymphatics: CO2 & HDT

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Planned-Funded - Task expected to be within budget

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1: To measure the effects of HDT positioning on human glymphatic function.

Specific Aim 2: To assess the combined effect of breathing elevated CO2 and HDT on

human glymphatic function.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

Quantification of the changes in blood–brain barrier (BBB) permeability and

structure in response to HDT with and without elevated CO2.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-201: Determine if altered atmospheric conditions (e.g., elevated ambient CO2, mild hypoxia from exploration atmosphere) has a contributing role in the development of ocular manifestations.

SANS-204: Determine if sleep/glymphatics has a contributing role in the development of ocular manifestations.

Effect of Head-Down Tilt +/- CO2 on Human Glymphatic Function

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SANS Risk Approach plan

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