HRR - Task - Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation

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Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Laiakis, Evagelia

Short Title: Metabolism Pathways in Skeletal Muscle

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: Identify metabolic perturbations in gastrocnemius and quadricep muscles through

metabolomics relating to space radiation and/or the μG analog HU, with focus on energy and

mitochondrial related pathways.

Aim 2: Determine whether the combined effects of radiation and HU exhibit an additive or

synergistic effect in metabolic pathways, with emphasis on cofactors that can be explored as

countermeasures.

Resources (None Listed)

Deliverables (1)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:

Radiation exposure can lead to perturbations in energy metabolism that could be additive or synergistic with μG. The investigators hypothesize that the space environment with ground based analogs (simulated μG via hindlimb unloading (HU) and simulated space radiation) will lead to exacerbated alterations in intramuscular energy metabolism in mice, such as in TCA cycle, fatty acid betaoxidation, and cofactors among others.

Internal Customers:
Human Health Countermeasures
Space Radiation
External Customers:
None

Mappings

Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

M14: Indentify adjuncts to exercise countermeasures that can be used to better mitigate muscle loss.

M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance