Task Epigenetic state modulation of radiation-induced DNA damage: Nanoscale modeling and validation.
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Epigenetic state modulation of radiation-induced DNA damage
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):

Aim 1: Build coarse-grained Monte Carlo simulations to sample chromatin fiber ensembles for selected epigenetic states based on data from human fibroblasts.

Aim 2. Simulate irradiation of chromatin fiber models and predict DNA break patterns.

Aim 3. Predict and DNA fragmentation patterns in different epigenetic states in IMR-90 fibroblasts and HUVECs after irradiation with a galactic cosmic ray model and X-rays.

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