Short Title:
Epigenetic state modulation of radiation-induced DNA damage
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Aim 1: Build coarse-grained Monte Carlo simulations to sample chromatin fiber ensembles for selected epigenetic states based on data from human fibroblasts.
Aim 2. Simulate irradiation of chromatin fiber models and predict DNA break patterns.
Aim 3. Predict and DNA fragmentation patterns in different epigenetic states in IMR-90 fibroblasts and HUVECs after irradiation with a galactic cosmic ray model and X-rays.
Category:
Technology or Tool
Subcategory:
Computational Models or Simulations
Description:
A framework for extrapolating complex DNA damage predictions from epigenome (chromatin state) data in human cells subjected to GCRs.
Internal Customers:
None
External Customers:
None