Short Title:
Space radiation exposure and risk mediated by clonal hematopoiesis.
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Simulated space radiation will promote clonal hematopoiesis and thereby impact
cardiovascular disease and leukemogenesis/cancer in a radiation- and gene-specific manner. This study (clonal hematopoiesis, cardiology, oncology, radiation biology) will employ
a novel murine adoptive bone marrow transfer approach to model clonal hematopoiesis induced
by somatic mutations in driver genes.
Experiments will examine the consequences of simulated GCR and SPE on:
(1) hematologic clone expansion
(2) cardiovascular function
(3) leukemogenic/cancer endpoints.
Other Resources
| Other Resources Needed?
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Yes
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Category:
Risk Characterization, Quantification
Subcategory:
Description:
Assess age-related degeneration, cancer end-points and mortality due to radiation exposure.
Internal Customers:
None
External Customers:
None