Task Space radiation exposure and risk mediated by clonal hematopoiesis.
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: Space radiation effects on clonal hematopoiesis
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Aim 1: Employ a novel murine adoptive bone marrow transfer approach to model clonal hematopoiesis induced by somatic mutations in TET2, DNMT3A, TP53 and PPM1D. 

Aim 2: Examine the consequences of simulated GCR and SPE on: (1) hematologic clone expansion (2) cardiovascular function (3) leukemogenic/cancer endpoints. 
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