Short Title:
In-silico and In-vivo models
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Specific Aim 1: Replicate the relative organ dose distribution seen in humans exposed to
radiation in deep space vehicles in an appropriate mammalian model(s).
Specific Aim 2: Identify functional and cellular indicators of cardiovascular function in a
mouse model of space-relevant radiation exposures.
Specific Aim 3: Determine which cardiovascular and GI outcomes of simulated GCR
exposure in the mouse translate to human organs on chip.
(note: Aims as modified post-selection)
Category:
Study Results
Subcategory:
Description:
- Validation of a novel approach that enables
accurate ground-based simulations of the intravehicular GCR environment without the need of
ion beam switching. Additionally, this new paradigm will facilitate research results that are The
ability to accurately simulate the space radiation environment in terrestrial research will facilitate
rapid advances in the radiobiological health during long-duration spaceflight.
- Identification in vivo functional and structural changes in the cardiovascular
system due to space-relevant GCR exposures. Moreover, comparisons with human organs-on a chip will indicate which cellular changes in the mouse model are translatable to a human system.
Additionally, this line of inquiry may provide evidence of relevance to controversial sex-specific
dose limits for astronauts.
Internal Customers:
None
External Customers:
None