Task Integration of In-Silico and In-Vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction.
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: In-silico and In-vivo models
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Specific Aim 1: Replicate the relative organ dose distribution seen in humans exposed to radiation in deep space vehicles in an appropriate mammalian model(s).

Specific Aim 2: Identify functional and cellular indicators of cardiovascular function in a mouse model of space-relevant radiation exposures.

Specific Aim 3: Determine which cardiovascular and GI outcomes of simulated GCR exposure in the mouse translate to human organs on chip. 

(note: Aims as modified post-selection)
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