Task Molecular Characterization of Transmissible Chromosome Aberrations Produced By Ions of Intermediate and High Atomic Number (directed task).
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Chromosome Aberrations II - Breakpoints
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Directed
Aims:

Aim 1: determine if analysis of IR-induced CA breakpoint junctions suggest different molecular pathways are involved, with respect high- versus low LET exposure.

Aim 2: determine if the sizes of co-deleted sequences at breakpoint junctions differ for those produced by high versus low LET IR; these may form the basis of an LET-dependent biomarker.

Aim 3: determine if the breakpoints associated with complex chromosomal exchanges are different than those associated with simple reciprocal exchanges that involve only two chromosomes.

Aim 4: At NASA’s discretion related to source availability and energies of interest, examine the breakpoint junctions of exchange aberrations induced by medium-to-high energy neutrons.

Aim 5:  At NASA’s discretion, characterize molecular differences between the breakpoints produced by different ultra-low dose ions.

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