Task Dose Rate Effects and GCR Simulation in Cancer Relevant Systems
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: Dose Rate Effects and GCR Simulation
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Planned-Funded - Task expected to be within budget
Procurement Mechanism(s):
Directed
Aims:
  • Test the hypothesis that the time between doses and the dose-rate are critical modulators of mutant frequency in human cells following exposure to a mixed GCR field. Cultured human TK6 lymphoblasts will be used and the results compared with data obtained previously with these cells using acute exposures to single ions or rapidly delivered sequential beams.

  • Test the hypothesis that the time between doses and dose-rate are critical modulators of mutational spectra following exposure to a mixed GCR field. We hypothesize that the types of TK1 mutations will be distinct from spontaneous events and that dose-rate and the time between exposures will alter the signature of radiogenic mutations.
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