HRR - Task - Nutritional Status Assessment: SMO-016E

Efficacy of Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamin D Supplementation in an Antarctic Ground Analog of Space Flight: Study of Supplementation Protocol and Relationship to Immune System Function

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamin D Supplement Evaluation of Dosing Requirements

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Dietary Intake Can Predict and Protect Against Changes in Bone Metabolism During Space Flight and Recovery (Pro-K)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

Characterization of Oxidative Damage During a Saturation Dive

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N6: What impact does the spaceflight environment have on oxidative damage?

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.

Vertebral Compression Fracture Assessment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Feasibility Study: QCT Modality for Risk Surveillance of Bone - Effects of In-flight Countermeasures on Sub-regions of the Hip Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Recovery of Musculoskeletal Quantity and Quality upon Multiple Microgravity Exposure

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long Duration Space Flight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Rapid measurements of bone loss using tracer-less calcium isotope analysis of blood and urine

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss: SMO-021

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Risk of Intervertebral Disc Damage After Prolonged Spaceflight

Common Item(s)
	Risk of Renal Stone Formation

The impact of modeled microgravity and prior radiation exposure on cytomegalovirus reactivation and host immune evasion

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning: An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones (Integrative CM-Levine, Completed)

Common Item(s)
	Risk of Renal Stone Formation

Microbial Risk Assessment and Integration

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Development of Spaceflight Foods with High Microbial Concentrations

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Immune Countermeasures Validation (Analog)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures

Validation of Procedures for Monitoring Crewmember Immune Function (Integrated Immune - SMO 015/SDBI 1900) Completed

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Flight-Induced Changes in Immune Defenses-DSO 498

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Incidence of Latent Virus Shedding During Space Flight-DSO 493

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Space Flight-Induced Reactivation of Latent Epstein-Barr Virus

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Consequences of Long-term Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment (CHOICE)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

LADTAG Lunar Dust Health Standard

Common Item(s)
	Risk of Renal Stone Formation

Data Mining for Incidence of Renal Stone Formation Following Spaceflight

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?

Renal Stone Risk during Spaceflight: Assessment and Countermeasure Validation (Renal Stone - DSO 633)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?

Clearance of Particles Depositing in the Human Lung in Low-Gravity

Common Item(s)
	Risk of Renal Stone Formation

Suited Contingency Ops Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of Processing and Subsequent Storage on Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vitamins B1 and C Degradation in Spaceflight Foods: Establishment of Prediction Models and Prevention Strategies

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Integration of Product, Package, Process, and Environment: A Food System Optimization

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effects of Retronasal Smelling, Variety, and Choice on Appetite and Satiety

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Comparative Packaging Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Bulk Overwrap Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Flexible High-Barrier Polymers for Food Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaged Food Mass Reduction Technology Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Food Processing vs. Packaged Food System Trade Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Stability of Pharmacotherapeutics and Nutrition Compounds - Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Thermostabilized Food Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effect of Space Radiation on the Nutrition and Quality of the Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Development of a Multipurpose Extruder/Press Food Processing System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

ElastiGlass Barrier Film and Food Processing Techniques for the 3 to 5 Year Shelf-Stable Food Package

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaged Food Mass Reduction Trade Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Total System Approach

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Reheating and Sterilization Technology for Food, Waste and Water

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

A Multipurpose Fruit and Vegetable Processing System for Advanced Life Support

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N6: What impact does the spaceflight environment have on oxidative damage?

Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Monitoring Bone Health by Daily Load Stimulus Measurement during Lunar Missions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

An Integrated Musculoskeletal Countermeasure Battery for Long-Duration Lunar Missions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Integrated Nutrition: Development and Provision of Functional Foods to Mitigate Bone Loss on ISS Missions

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.3: We need to identify the most important nutritional factors for ocular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.

Monitoring of Bone Loss Biomarkers in Human Sweat: A Non-Invasive, Time Efficient Means of Monitoring Bone Resorption Markers under Micro and Partial Gravity Loading Conditions

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Extent, Causes, and Countermeasures of Impaired Fracture Healing in Hypogravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Space Radiation and Bone Loss: Lunar Outpost Mission Critical Scenarios and Countermeasures

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Maintaining Musculoskeletal Health in the Lunar Environment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Ultrasound Fracture Diagnosis in Space

Common Item(s)
	Risk of Renal Stone Formation

Combined Scanning Confocal Ultrasound Diagnostic and Treatment System for Bone Quality Assessment and Fracture Healing

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Renal Stone Formation
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Reusable Handheld Electrolytes and Lab Technology for Humans

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Renal Stone Formation

Pilot Studies of Radiation Damage in Organ Tissues of Mice

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Sonographic Astronaut Vertebral Examination

Common Item(s)
	Risk of Renal Stone Formation

Retrospective Study of Serum Sclerostin Measurements in Bedrest Subjects

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Pharmaceutical Countermeasure Effects on Tissue-level Quality of Immobilized Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Simulated Microgravity and Radiation-Induced Bone Degeneration: Oxidative Stress- and p53-Dependent Mechanisms

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Factors Contributing to Food Acceptability and Consumption, Mood, and Stress on Long-term Space Missions/Food Variety in Free-Living Adults

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

The Effects of Long-Term Exposure to Microgravity on Salivary Markers of Innate Immunity

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Development of Capability to Monitor and Treat Disease Caused by Dust Exposure During Exploration Missions

Common Item(s)
	Risk of Renal Stone Formation

Integrated Medical Model - Renal Stone Module

Common Item(s)
	Risk of Renal Stone Formation

Immune Countermeasures Validation - Flight

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Dual Use Packaging

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Advanced Cookware and Techniques for Food Preparation at Reduced Pressure and Gravity

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Evaluate Energy Expenditure During Long-duration (>3mo) Missions.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.

Defining the relationship between biomarkers of oxidative and inflammatory stress and atherosclerosis risk in astronauts during and after long-duration spaceflight (Cardio Ox-Lee, Active)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.

Simulated space radiation and weightlessness: vascular-bone coupling mechanisms to preserve skeletal health

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N6: What impact does the spaceflight environment have on oxidative damage?

Evaluation of the effect of short duration spaceflight on hepatic nutrition, oxidative damage, and colon microflora

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N6: What impact does the spaceflight environment have on oxidative damage?

Examination of Splenic and Thymic Immune Function in Mice (STS-135 Mouse Tissue Sharing Pilot Study)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Evaluation of the combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rats (Immune Assessment)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Fracture Healing in Haversian Bone under Conditions of Simulated Microgravity

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Effects of high dietary heme iron and radiation on cardiovascular function (Radiation/Iron, CVD-Westby, Completed)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.

Bone Turnover Model: Initial Implementation

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Evaluation of a sclerostin antibody in mice as a novel promoter of bone formation during spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Non-Thermal Sanitation By Atmospheric Pressure Plasma

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Induction of Early Stages of Osteoarthritis After Exposure to Microgravity (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Developing a new bone medical standard for long-duration astronauts based on bone strength estimated by Finite Element [FE] Modeling

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Increasing the Efficiency of Exercise Countermeasures for Bone Loss

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Nutritional countermeasures to ameliorate losses in muscle mass and function

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.

A Low Intensity Mechanical Countermeasure to Prohibit Osteoporosis in Astronauts During Long-Term Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Evaluation of Host-Pathogen Interactions During Exposure to Microgravity Analogues -- ASU Grant

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Examination of Anti-Resorptive and Anabolic Treatments/Stimuli on Unloading Induced Osteoporosis

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Bone Recovery Potential After Bisphosphonate and PTH Treatment of Disuse Osteoporosis

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Data mining activities for Bone Discipline

Common Item(s)
	Risk of Renal Stone Formation

Retention of Skeletal, Musculature, and Postural Status with a Non-invasive, Extremely Low-level Mechanical Signal: A Ground-based Evaluation of Efficacy

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH/COMPLETED]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.3: We need to identify the most important nutritional factors for ocular health.

Clinical Immunology Study - European Collaboration

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Concordia: D, Immune and Metabolism

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.5: We need to identify the most important nutritional factors for immune health.

Space Biochemistry Profile

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N3.3: We need to determine changes in nutritional status due to spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.3: We need to identify the most important nutritional factors for ocular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.

Nutrition/Pharm Interactions

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?

Stable Calcium Isotopes in Urine as a Biomarker of Bone Mineral Balance in Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE/ACTIVE]

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.3: We need to identify the most important nutritional factors for ocular health.

Novel Double-Hit Mouse Model to Investigate Oxidative Damage from Radiation/ Hyperoxia Related to Space Exploration - Evaluation of Dietary Flaxseed as Countermeasure

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Stabilized Foods for Use in Extended Spaceflight: Preservation of Shelf-Life, Nutrient Content and Acceptability

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Suited Contingency Ops Food - 2

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Understanding Kinetics of Nutrient Degradation in Foods-2

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Digital Astronaut: Bone Remodeling Model

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Renal Stone Formation

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Lab Analysis Point-of-Care Device Evaluation and Downselect (TBD)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Functional immune alterations, latent Herpesvirus reactivation, physiological stress and clinical incidence onboard the International Space Station

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Literature review of factors affecting food and nutrient stability

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Bioavailability of Nutrients in Food

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Packaging Configuration

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Prepackaged Food System Database

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Trade Space Develop

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Trade Methodology Recommendations

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Food Fortification Stability Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Functional Foods Baseline and Requirements Analysis

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

New Crop Testing: Nutritional & Organoleptic Analysis

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Data Mining for Bone Research and Clinical Advisory Panel (RCAP)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Immune Clinical Correlations

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Prevention of Renal Stone Complications in Space Exploration

Common Item(s)
	Risk of Renal Stone Formation

Portable Quantitative Ultrasound with DXA/QCT and FEA Integration for Human Longitudinal Critical Bone Quality Assessment

Common Item(s)
	Risk of Renal Stone Formation

Delivery of Probiotics in the Space Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Can Benefits from a Single Administration of Bisphosphonates Extend to a Second Later Exposure to Microgravity?

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Effects of Angiotensin Converting Enzyme Inhibitors on Bone Turnover

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

(NEEMO Nut ROI) Oxidative Damage During a 12-day Saturation Dive

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N6: What impact does the spaceflight environment have on oxidative damage?

Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Meal Replacement Mass Reduction and Integration Acceptability Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick-and-Eat Salad-Crop Productivity, Nutritional Value, and Acceptability to Supplement the ISS Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick and Eat Crop Selection Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Dwarf Fruit Production Study

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Pick and Eat Salad Crop Testing

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Precise Automated Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Surface Crop Expansion Beyond Pick and Eat

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Sustained Veggie Ground and Flight

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Processing and Preparation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Surface Food System - Ingredient Functionality/Formulation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Vertebral strength and fracture risk following long duration spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Monitoring the Cellular Immunity by in vitro Delayed Type Hypersensitivity Assay on ISS

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Biochemical Occupational Surveillance

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.3: We need to identify the most important nutritional factors for ocular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.

Optimal Nutrition Occupational Surveillance

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	Risk of Renal Stone Formation
	N13: Can renal stone risk be decreased using nutritional countermeasures?
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N4: Does mission architecture and/or available countermeasures impact nutritional status of crewmembers during spaceflight?
	N6: What impact does the spaceflight environment have on oxidative damage?
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.
	N7.3: We need to identify the most important nutritional factors for ocular health.
	N7.4: We need to identify the most important nutritional factors for behavior and performance.
	N7.5: We need to identify the most important nutritional factors for immune health.

Skeletal Responses to Long-Duration Simulated Microgravity in Male and Female Rats (Globus)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Sclerostin's role in regulating bone formation during long-term simulated microgravity and subsequent recovery (Bloomfield)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Assessment of Structural and Functional Knee Joint Degradation During Modeled Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Effect of Unloading on the Structure and Mechanics of Rotator Cuff Tendon-to-Bone Insertion

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Whole Joint Health: Investigating Modeled Spaceflight Changes in Mice (Postdoctoral Fellowship)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Deep Space Exploration Atmosphere Effects on Hematologic, Immunologic, and Oxidative Stress and Damage Parameters in Astronauts: An ISS Flight Study

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N6: What impact does the spaceflight environment have on oxidative damage?

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Astronaut Bone Medical Standards Derived from Finite Element (FE) Modeling of QCT Scans from Population Studies and Astronauts (Phase II)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Improvement of Shelf Life for Space Food Through Hurdle Approach

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Consequences of longterm-confinement and hypobaric hypoxia on immunity in the Antarctic Concordia Environment: from observations to mechanisms

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Evaluation of an Impedance Threshold Device as a Vision Impairment and Intracranial Pressure (VIIP) Countermeasure [IMPEDANCE THRESHOLD COUNTERMEASURE/EBERT/ACTIVE]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.3: We need to identify the most important nutritional factors for ocular health.

Bioregenerative Food System Database

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

High-Protein And Polyphenol Bar Formulations: Utilizing Whey Protein-Polyphenol Ingredients

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	IM-401: Test, optimize and validate nutrition-based preventive/mitigative countermeasures
	N7.5: We need to identify the most important nutritional factors for immune health.

Improving Kidney Stone Detection in Space Analogs

Common Item(s)
	Risk of Renal Stone Formation

Wearable, Sustained Acoustic Medicine for Back Pain

Common Item(s)
	Risk of Renal Stone Formation

Flexible Ultrasound System for Quantitative Diagnosis and Therapeutic Ultrasound

Common Item(s)
	Risk of Renal Stone Formation

VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study [1C-PCOS/SMITH/ACTIVE]

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.3: We need to identify the most important nutritional factors for ocular health.

Effects of space flights on the proteome of astronauts' plasma (Rithidech) functional immune

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

DNA damage in the ISS astronaut's lymphocytes and their association with stress-induced immune dysfunction (Honglu Wu) Functional immune

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Candidate nutritional countermeasure to mitigate adverse effects of spaceflight (Schreurs)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

An Integrated Framework for Characterization of the Noncoding Genome and Epigenome in Astronauts (Mason)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N6: What impact does the spaceflight environment have on oxidative damage?

The impact of long duration spaceflight on the function of B-cells and biomarkers of inflammation (Spielmann)

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Food Radiation Validation FTO

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Assessment of Normoxic Coastal Antarctic Winterover as an Analog for Spaceflight Immune Dysregulation

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Mitigating radiation-induced bone loss via dietary modulation of inflammatory cytokines (Bloomfield)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.
	Osteo 7: We need to identify options for mitigating early onset osteoporosis before, during and after spaceflight.

Food Acceptability, Menu Fatigue, and Aversion on ISS Missions

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Baseline Microbial Assessment of Fresh Produce

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.
	N7.3: We need to identify the most important nutritional factors for ocular health.
	N7.5: We need to identify the most important nutritional factors for immune health.

Spaceflight-Induced Changes in Microbial Virulence and the Impact to the Host Immune Response

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

2020 Cross-Species Rodent ISS Study: CVD/late CNS Clinical Model #1 (chronic study)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N15: We need to identify the most important nutritional factors for oxidative damage during spaceflight.

Immune Countermeasure

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Renal Stone Management Technology Development and Clinical Validation Study

Common Item(s)
	Risk of Renal Stone Formation

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

CBS VNSCOR #1: Responses of the Nervous System to Chronic, Low Dose Charged Particle Irradiation

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

BioNutritional Countermeasures Data Mining

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.4: We need to identify the most important nutritional factors for behavior and performance.

Identification, Development, and Validation of Countermeasures to Counter Synergistic Effects of Space Radiation on CNS/BMed/SM (CBS) Risk Areas (NRA)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.4: We need to identify the most important nutritional factors for behavior and performance.

Pilot Assessment of Stress and Latent Herpesvirus Reactivation at Palmer, Antarctica - Platform for Validation of Immune Countermeasures?

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Quantitative Microbial Risk Assessment: Exploring the Microbiome at the International Space Station to Develop Food Production Systems

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Space Food System Microbial Requirements Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Molecular-based Environmental Microbial Monitoring of Cropped Based Food System

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Understanding Kinetics of Nutrient Degradation in Foods-3

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

[SMT] Exploration Food System Program Evaluation

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Produce Safety Methods

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

GMO Crops

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Advanced Crop Hardware Testing

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Effect of Simulated Solar Particle Events and Galactic Cosmic Rays on Crop Growth and Development

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Varicella Zoster virus shedding after antiviral drug (Valacyclovir) treatment in Antarctic expeditioners

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Exploration Atmosphere Bedrest

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

EVALUATING RESISTIVE EXERCISE AS A LONG-TERM COUNTERMEASURE FOR SPACEFLIGHT-INDUCED BONE LOSS USING CALCIUM ISOTOPES (Romaniello)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Downs)

Common Item(s)
	Risk of Inadequate Nutrition
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
	N7.1: We need to identify the most important nutritional factors for musculoskeletal health.
	N7.2: We need to identify the most important nutritional factors for cardiovascular health.

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 4: We don't know the contribution of each risk factor on bone loss and recovery of bone strength, and which factors are the best targets for countermeasure application.

rHealth One Flight Demonstration

Common Item(s)
	Risk of Renal Stone Formation

Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

MinION Viral Detection

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Awakening endogenous retroviruses with the space environment

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

The impact of human spaceflight on clonal hematopoiesis

Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response

Bacillus spore probiotics: evaluation of survival and efficacy after exposure to deep-space radiation simulating long-duration human exploration missions

Common Item(s)
	Risk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition

Printed Electrochemical Sensor Strip for Quantifying Bone Density Loss in Microgravity (Koehne)

Common Item(s)