Short Title:
Hip QCT
Responsible HRP Element:
Human Health Countermeasures
Collaborating Org(s):
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Research Operations and Integration (ROI) |
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Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
This study will describe in each astronaut:
- How the QCT-measured changes in hip bone BMD and in the cross-sectional areas of cortical and trabecular bone correspond to different mitigating approaches to bone loss, i.e., biochemical or biomechanical, either in combination or singly.
- How the above QCT-measured changes in hip bone morphology translate to hip bone fracture loads (aka, “hip bone strength”) as determined by FE Modeling of QCT data.
- How QCT-measured changes in hip bone morphology during postflight period translate to the recovery of baseline (i.e., preflight) FEM-derived hip bone strength after a mission on-board the International Space Station.
Integration/Unique Aspects: Task will contribute to standard update in NASA-STD-3001.
Category:
Standard
Subcategory:
Update
Description:
Generated FE strength data from astronauts to be added to dataset from which FE-strength cutoffs are derived as proposed medical standards.
This Task contributes to Osteo 6 by generating hip structural data to inform the Bone Fracture Risk Module of Integrated Medical Model.
Internal Customers:
None
External Customers:
Office of Chief Health and Medical Officer (OCHMO)
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Requirement
Subcategory:
Guidelines/Criteria
Description:
Testing feasibility of QCT modality as a surveillance method in long-duration astronauts.
This Task contributes to Osteo 1 by generating FE strength data from astronauts to refine the dataset from which FE-strength cutoffs are derived as proposed medical standards.
This Task contributes to Osteo 5 by generating requirements for in-flight monitoring for changes in bone mass.
Internal Customers:
None
External Customers:
Med Ops - Medical Operations
Is a Customer-Supplier Agreement (CSA) Required?
No
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Hip structural data as generated by QCT modality to inform Bone Fracture Risk Module of Integrated Medical Model.
This Task contributes to Osteo 3 as evidence-based method for assessing a clinical trigger for osteoporosis as identified by a Bone RCAP, and possibly as required by Osteo 1.
This Task contributes to Osteo 4 by quantifying declines in hip bone strength with spaceflight as a risk factor for fracture.
This Task contributes to Osteo 7 by generating pilot data that describes the efficacy of countermeasures in terms of mitigating declines in bone strength.
Internal Customers:
Human Health Countermeasures
External Customers:
None